HuLPr16483

Uniprot ID

CTNA2_HUMAN

Uniprot Acc

P26232;B3KXE5;B7Z2W7;B7Z352;B7Z898;Q4ZFW1;Q53R26;Q53R33;Q53T67;Q53T71;Q53TM8;Q7Z3L1;Q7Z3Y0;

Protein name

Catenin alpha-2

Comment

FUNCTION:May function as a linker between cadherin adhesion receptors and the cytoskeleton to regulate cell-cell adhesion and differentiation in the nervous system. Regulates morphological plasticity of synapses and cerebellar and hippocampal lamination during development. Functions in the control of startle modulation (By similarity).||SUBUNIT:Interacts with ZNF639.||SUBCELLULAR LOCATION:Cytoplasm. Cytoplasm, cytoskeleton (By similarity). Cell junction, adherens junction (By similarity). Cell membrane; Peripheral membrane protein; Cytoplasmic side (By similarity). Cell projection, axon (By similarity). Note=Recruited to the nucleus upon ZNF639 overexpression.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=6; Name=1; Synonyms=AlphaN-catenin II; IsoId=P26232-1; Sequence=Displayed; Name=2; Synonyms=AlphaN-catenin I; IsoId=P26232-2; Sequence=VSP 020337; Name=3; IsoId=P26232-3; Sequence=VSP 038009; Note=No experimental confirmation available; Name=4; IsoId=P2623

Subcellular localization

Cytoplasm.Cytoplasm, cytoskeleton(By similarity).Cell junction, adherens junction(By similarity).Cell membrane;Peripheral membrane protein;Cytoplasmic side(By similarity).Cell projection, axon(By similarity).

Gene name

catenin (cadherin-associated protein), alpha 2

Protein sequence

MTSATSPIILKWDPKSLEIRTLTVERLLEPLVTQVTTLVN TSNKGPSGKKKGRSKKAHVLAASVEQATQNFLEKGEQIA KESQDLKEELVAAVEDVRKQGETMRIASSEFADDPCSSV KRGTMVRAARALLSAVTRLLILADMADVMRLLSHLKIVE EALEAVKNATNEQDLANRFKEFGKEMVKLNYVAARRQQE LKDPHCRDEMAAARGALKKNATMLYTASQAFLRHPDVAA TRANRDYVFKQVQEAIAGISNAAQATSPTDEAKGHTGIG ELAAALNEFDNKIILDPMTFSEARFRPSLEERLESIISG AALMADSSCTRDDRRERIVAECNAVRQALQDLLSEYMNN TGRKEKGDPLNIAIDKMTKKTRDLRRQLRKAVMDHISDS FLETNVPLLVLIEAAKSGNEKEVKEYAQVFREHANKLVE VANLACSISNNEEGVKLVRMAATQIDSLCPQVINAALTL AARPQSKVAQDNMDVFKDQWEKQVRVLTEAVDDITSVDD FLSVSENHILEDVNKCVIALQEGDVDTLDRTAGAIRGRA ARVIHIINAEMENYEAGVYTEKVLEATKLLSETVMPRFA EQVEVAIEALSANVPQPFEENEFIDASRLVYDGVRDIRK AVLMIRTPEELEDDSDFEQEDYDVRSRTSVQTEDDQLIA GQSARAIMAQLPQEEKAKIAEQVEIFHQEKSKLDAEVAK WDDSGNDIIVLAKQMCMIMMEMTDFTRGKGPLKNTSDVI NAAKKIAEAGSRMDKLARAVADQCPDSACKQDLLAYLQR IALYCHQLNICSKVKAEVQNLGGELIVSGTGVQSTFTTF YEVDCDVIDGGRASQLSTHLPTCAEGAPIGSGSSDSSML DSATSLIQAAKNLMNAVVLTVKASYVASTKYQKVYGTAA VNSPVVSWKMKAPEKKPLVKREKPEEFQTRVRRGSQKKHISPVQALSEFKAMDSF

Database cross reference

RefSeq Protein accession:NP_001158355
RefSeq Protein gi:259013216

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Fetal Liver;Human Liver Organelles;

GO:0015629;C:actin cytoskeleton;IEA:InterPro. GO:0030424;C:axon;ISS:UniProtKB. GO:0005829;C:cytosol;TAS:Reactome.

GO-F

GO:0045296;F:cadherin binding;IEA:InterPro. GO:0005200;F:structural constituent of cytoskeleton;NAS:UniProtKB.

GO-P

GO:0007409;P:axonogenesis;ISS:UniProtKB. GO:0048854;P:brain morphogenesis;ISS:UniProtKB. GO:0016337;P:cell-cell adhesion;ISS:UniProtKB. GO:0048813;P:dendrite morphogenesis;ISS:UniProtKB. GO:0042692;P:muscle cell differentiation;TAS:Reactome. GO:005114

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr16483

ACETYLATION

889

K

PhosphoSitePlus

11323594

HTP

N

HuLPr16483

PHOSPHORYLATION

321

S

PhosphoSitePlus

3652688

HTP

N

HuLPr16483

PHOSPHORYLATION

640

S

PhosphoSitePlus

454324

LTP

N

HuLPr16483

PHOSPHORYLATION

651

S

PhosphoSitePlus

2023333

LTP

N

HuLPr16483

PHOSPHORYLATION

653

T

PhosphoSitePlus

2023337

LTP

N

HuLPr16483

PHOSPHORYLATION

132

S

PhosphoSitePlus

2525646

LTP

N

HuLPr16483

PHOSPHORYLATION

151

S

PhosphoSitePlus

2525649

HTP

N

HuLPr16483

PHOSPHORYLATION

135

T

PhosphoSitePlus

2525652

LTP

N

HuLPr16483

PHOSPHORYLATION

417

Y

PhosphoSitePlus

1025989

HTP

N

HuLPr16483

PHOSPHORYLATION

654

S

PhosphoSitePlus

2049073

LTP

N

HuLPr16483

PHOSPHORYLATION

657

T

PhosphoSitePlus

2049077

LTP

N