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Gene, Transcriptome, Protein, Pathway or Disease. 

Protein basic information

LiverAtlas Protein ID

HuLPr16498

Uniprot ID

CTRC_HUMAN

Uniprot Acc

Q99895;A8K082;O00765;Q9NUH5;

Protein name

Chymotrypsin-C

Comment

FUNCTION:Has chymotrypsin-type protease activity and hypocalcemic activity.||CATALYTIC ACTIVITY:Preferential cleavage:Leu-|-Xaa, Tyr-|-Xaa, Phe-|-Xaa, Met-|-Xaa, Trp-|-Xaa, Gln-|-Xaa, Asn-|-Xaa.||TISSUE SPECIFICITY:Pancreas.||DISEASE:Variations in CTRC influence susceptibility to chronic pancreatitis [MIM:167800]. Chronic pancreatitis is a persistent inflammatory disorder characterized by permanent destruction of the pancreatic parenchyma.||SIMILARITY:Belongs to the peptidase S1 family. Elastase subfamily.||SIMILARITY:Contains 1 peptidase S1 domain.

Gene name

chymotrypsin C (caldecrin)

Protein sequence

MLGITVLAALLACASSCGVPSFPPNLSARVVGGEDARPHS WPWQISLQYLKNDTWRHTCGGTLIASNFVLTAAHCISNT RTYRVAVGKNNLEVEDEEGSLFVGVDTIHVHKRWNALLL RNDIALIKLAEHVELSDTIQVACLPEKDSLLPKDYPCYV TGWGRLWTNGPIADKLQQGLQPVVDHATCSRIDWWGFRV KKTMVCAGGDGVISACNGDSGGPLNCQLENGSWEVFGIV SFGSRRGCNTRKKPVVYTRVSAYIDWINEKMQL

Database cross reference

RefSeq Protein accession:NP_009203
RefSeq Protein gi:62526043

Liver relevance

HLPP validation

Yes/No

Yes

Project name

French Liver;Human Fetal Liver;Human Liver Organelles;

Ontology annotation

GO-F

GO:0004252;F:serine-type endopeptidase activity;IEA:InterPro.

GO-P

GO:0006508;P:proteolysis;TAS:ProtInc.

Pathway

Pathway name

Urokinase-type_plasminogen_activator_(uPA)_and_uPAR-mediated_signaling