HuLPr16628

Uniprot ID

CXL14_HUMAN

Uniprot Acc

O95715;B3KQU8;Q6UW97;Q86U69;Q9BTR1;Q9NS21;

Protein name

C-X-C motif chemokine 14

Comment

FUNCTION:Potent chemoattractant for neutrophils, and weaker for dendritic cells. Not chemotactive for T-cells, B-cells, monocytes, natural killer cells or granulocytes. Does not inhibit proliferation of myeloid progenitors in colony formation assays.||SUBCELLULAR LOCATION:Secreted.||TISSUE SPECIFICITY:Expressed in heart, brain, placenta, lung, liver, skeletal muscle, kidney and pancreas. Highly expressed in normal tissue without inflammatory stimuli and infrequently expressed in cancer cell lines. Weakly expressed in monocyte- derived dendritic cells. Not detected in lung or unstimulated peripheral blood lymphocytes.||INDUCTION:Up-regulated in peripheral blood lymphocytes in response to bacterial lipopolysaccharides (LPS).||SIMILARITY:Belongs to the intercrine alpha (chemokine CxC) family.||CAUTION:It is uncertain whether Met-1 or Met-13 is the initiator.||SEQUENCE CAUTION:Sequence=AAD38944.1; Type=Erroneous initiation;||WEB RESOURCE:Name=Wikipedia; Note=CXCL14 entry; URL="http://en.wi

Subcellular localization

Secreted.

Gene name

chemokine (C-X-C motif) ligand 14

Protein sequence

MSLLPRRAPPVSMRLLAAALLLLLLALYTARVDGSKCKCS RKGPKIRYSDVKKLEMKPKYPHCEEKMVIITTKSVSRYR GQEHCLHPKLQSTKRFIKWYNAWNEKRRVYEE

Database cross reference

RefSeq Protein accession:NP_004878
RefSeq Protein gi:20149565

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;Chinese Liver;

GO:0005615;C:extracellular space;IEA:UniProtKB-KW. GO:0005794;C:Golgi apparatus;IDA:LIFEdb.

GO-F

GO:0008009;F:chemokine activity;TAS:ProtInc.

GO-P

GO:0007267;P:cell-cell signaling;TAS:ProtInc. GO:0006935;P:chemotaxis;TAS:ProtInc. GO:0006955;P:immune response;IEA:InterPro. GO:0007165;P:signal transduction;TAS:ProtInc.

TSH