HuLPr18126

Uniprot ID

DACT2_HUMAN

Uniprot Acc

Q5SW24;Q2NKJ2;Q569G0;Q8WYW2;

Protein name

Dapper homolog 2

Comment

FUNCTION:Negatively regulates the Nodal signaling pathway, possibly by promoting the lysosomal degradation of Nodal receptors (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q5SW24-1; Sequence=Displayed; Name=2; IsoId=Q5SW24-2; Sequence=VSP 032596; Note=No experimental confirmation available; Name=3; IsoId=Q5SW24-3; Sequence=VSP 032595; Note=No experimental confirmation available; Name=4; IsoId=Q5SW24-4; Sequence=VSP 032597, VSP 032598; Note=No experimental confirmation available;||DOMAIN:The C-terminal PDZ-binding motif may mediate interaction with the PDZ domains of DSH (Dishevelled) family proteins (By similarity).||SIMILARITY:Belongs to the dapper family.||SEQUENCE CAUTION:Sequence=AAI11791.1; Type=Erroneous initiation; Sequence=AAL55843.1; Type=Frameshift; Positions=247;

Gene name

dapper, antagonist of beta-catenin, homolog 2 (Xenopus laevis)

Protein sequence

MWTPGGPPGSAGWDRRRLGARLRAAFAGLQELQGLRATQQ ERVRGALALQPPPAPAAPCGPHGLHGPEQQLEAALAALQ EQLSRLRQQDIGLKTHLDQLDLQISKLQLDVGTASGEAL DSDSRPSSGFYEMSDGGSCSLSTSCASVCSDHISPSLGS LLPVAQAHKARPSMGDWRPRSVDETTVPAWRPQATEEGA RPPGSVEDAGQPWGTFWPRPVSTGDLDRALPADTGLQKA SADAELLGLLCQGVDIPLHVPDPKYRQDLVSQGGREVYP YPSPLHAVALQSPLFVLTKETPQRGGPSFPRESPRGPAG LNTIQTGPVLEAGPARARAYIDRLLHLWGRETPAKGSEG EQGPLRHAASPSPQRQGGWSTDGGGRLLVFAPGREDEGG PAQSRGAGRGGPQQQGYMPLEGPQQSGSLPEEGSKPSNS CVLRETMVQASPSSKAQQTPSAQDYGRGNIISPSRMLDK SPSPASGHFAHPSFAASLKMGPPKSKAEKIKRSPMDKVL RFARQPLLLLDRPEGAHAAPQPSLEWDPAHWPTGRGGLQ RRPALAWEAPGRSCSESTLYPMPVLVPLAVAPQESHRTS AQALFPFEASLLTSVARRKHRRWQSTVEISARARLASCP ESNLGPPRPVARRAGGPLARGRPSLVRQDAYTRSDSEPS KHSAECDPRFPSVIPETSEGESSDHTTNRFGDRESSSSD EEGGAQSRDCDLALGYVAAGHAELAWTQEAPVSSGPLLS PVPKLCRIKASKALKKKIRRFQPTALKVMTMV

Database cross reference

RefSeq Protein accession:NP_999627
RefSeq Protein gi:163965434

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;

TGF-beta_receptor_signaling