Protein basic information
| LiverAtlas Protein ID |
HuLPr18130 |
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Uniprot ID |
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Uniprot Acc |
Q14118;A8K6M7;Q969J9; |
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Protein name |
Dystroglycan |
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Comment |
FUNCTION:The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sacrolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.||FUNCTION:Alpha-dystroglycan is an extracellular peripheral glycoprotein that acts as a receptor for both extracellular matrix proteins containing laminin-G domains, and for certain adenoviruses. Receptor for laminin-2 (LAMA2) and agrin in peripheral nerve Schwann cells. Also acts as a receptor for M.leprae in peripheral nerve Schwann cells but only in the presence of the G-domain of LAMA2, and for lymphocytic choriomeningitis virus, Old World Lassa fever virus, and clade C New World arenaviruses.||FUNCTION:Beta-dystroglycan is a transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN a |
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Subcellular localization |
Alpha-dystroglycan:Secreted, extracellular space. |
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Gene name |
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Related liver disease name |
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Protein sequence
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MRMSVGLSLLLPLSGRTFLLLLSVVMAQSHWPSEPSEAVR DWENQLEASMHSVLSDLHEAVPTVVGIPDGTAVVGRSFR VTIPTDLIASSGDIIKVSAAGKEALPSWLHWDSQSHTLE GLPLDTDKGVHYISVSATRLGANGSHIPQTSSVFSIEVY PEDHSELQSVRTASPDPGEVVSSACAADEPVTVLTVILD ADLTKMTPKQRIDLLHRMRSFSEVELHNMKLVPVVNNRL FDMSAFMAGPGNAKKVVENGALLSWKLGCSLNQNSVPDI HGVEAPAREGAMSAQLGYPVVGWHIANKKPPLPKRVRRQ IHATPTPVTAIGPPTTAIQEPPSRIVPTPTSPAIAPPTE TMAPPVRDPVPGKPTVTIRTRGAIIQTPTLGPIQPTRVS EAGTTVPGQIRPTMTIPGYVEPTAVATPPTTTTKKPRVS TPKPATPSTDSTTTTTRRPTKKPRTPRPVPRVTTKVSIT RLETASPPTRIRTTTSGVPRGGEPNQRPELKNHIDRVDA WVGTYFEVKIPSDTFYDHEDTTTDKLKLTLKLREQQLVG EKSWVQFNSNSQLMYGLPDSSHVGKHEYFMHATDKGGLS AVDAFEIHVHRRPQGDRAPARFKAKFVGDPALVLNDIHK KIALVKKLAFAFGDRNCSTITLQNITRGSIVVEWTNNTL PLEPCPKEQIAGLSRRIAEDDGKPRPAFSNALEPDFKAT SITVTGSGSCRHLQFIPVVPPRRVPSEAPPTEVPDRDPE KSSEDDVYLHTVIPAVVVAAILLIAGIIAMICYRKKRKG KLTLEDQATFIKKGVPIIFADELDDSKPPPSSSMPLILQ EEKAPLPPPEYPNQSVPETTPLNQDTMGEYTPLRDEDPN APPYQPPPPFTAPMEGKGSRPKNMTPYRSPPPYVPP |
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Database cross reference |
RefSeq Protein accession:NP_001159400
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Liver relevance
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HCC significant Proteins |
Yes/No |
Yes |
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Quality score |
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005604;C:basement membrane;IDA:UniProtKB. GO:0070938;C:contractile ring;IDA:UniProtKB. GO:0005737;C:cytoplasm;IDA:UniProtKB. GO:0005856;C:cytoskeleton;IEA:UniProtKB-SubCell. GO:0016010;C:dystrophin-associated glycoprotein complex;IDA:UniProtKB. GO |
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GO-F |
GO:0003779;F:actin binding;IDA:UniProtKB. GO:0051393;F:alpha-actinin binding;IDA:UniProtKB. GO:0005509;F:calcium ion binding;IEA:InterPro. GO:0043237;F:laminin-1 binding;ISS:UniProtKB. GO:0008307;F:structural constituent of muscle;IMP:UniProtKB. GO:00 |
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GO-P |
GO:0007016;P:cytoskeletal anchoring at plas |