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Protein basic information

LiverAtlas Protein ID

HuLPr18152

Uniprot ID

DB118_HUMAN

Uniprot Acc

Q96PH6;Q17RC4;Q8N691;Q9NUH0;

Protein name

Beta-defensin 118

Comment

FUNCTION:Has antibacterial activity (Potential).||SUBCELLULAR LOCATION:Secreted.||TISSUE SPECIFICITY:High-level and epididymis-specific expression. Most abundant in the epithelium of the caput and is also present in the lumen and bound to sperm. Expressed also in pancreas.||SIMILARITY:Belongs to the beta-defensin family.

Subcellular localization

Secreted.

Gene name

defensin, beta 118

Protein sequence

MKLLLLALPMLVLLPQVIPAYSGEKKCWNRSGHCRKQCKD GEAVKDTCKNLRACCIPSNEDHRRVPATSPTPLSDSTPG IIDDILTVRFTTDYFEVSSKKDMVEESEAGRGTETSLPN VHHSS

Database cross reference

RefSeq Protein accession:NP_473453
RefSeq Protein gi:16905373

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Human Fetal Liver;Human Liver Organelles;Chinese Liver;French Liver;

Ontology annotation

GO-C

GO:0005576;C:extracellular region;IEA:UniProtKB-SubCell.

GO-P

GO:0007160;P:cell-matrix adhesion;NAS:UniProtKB. GO:0042742;P:defense response to bacterium;TAS:UniProtKB. GO:0045087;P:innate immune response;TAS:UniProtKB. GO:0007283;P:spermatogenesis;NAS:UniProtKB.