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Protein basic information

LiverAtlas Protein ID

HuLPr18202

Uniprot ID

DCBD2_HUMAN

Uniprot Acc

Q96PD2;B7WNL1;D3DN41;Q8N6M4;Q8TDX2;

Protein name

Discoidin, CUB and LCCL domain-containing protein 2

Comment

SUBCELLULAR LOCATION:Membrane; Single-pass type I membrane protein.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96PD2-1; Sequence=Displayed; Name=2; IsoId=Q96PD2-2; Sequence=VSP 010715; Note=No experimental confirmation available;||TISSUE SPECIFICITY:Highly expressed in testis, heart, skeletal muscle and also in cultured vascular smooth muscle cells.||INDUCTION:Increased in lung cancers during the process of tumor progression.||SIMILARITY:Contains 1 CUB domain.||SIMILARITY:Contains 1 F5/8 type C domain.||SIMILARITY:Contains 1 LCCL domain.

Subcellular localization

Membrane;Single-pass type I membrane protein.

Gene name

discoidin, CUB and LCCL domain containing 2

Protein sequence

MASRAVVRARRCPQCPQVRAAAAAPAWAALPLSRSLPPCS NSSSFSMPLFLLLLLVLLLLLEDAGAQQGDGCGHTVLGP ESGTLTSINYPQTYPNSTVCEWEIRVKMGERVRIKFGDF DIEDSDSCHFNYLRIYNGIGVSRTEIGKYCGLGLQMNHS IESKGNEITLLFMSGIHVSGRGFLASYSVIDKQDLITCL DTASNFLEPEFSKYCPAGCLLPFAEISGTIPHGYRDSSP LCMAGVHAGVVSNTLGGQISVVISKGIPYYESSLANNVT SVVGHLSTSLFTFKTSGCYGTLGMESGVIADPQITASSV LEWTDHTGQENSWKPKKARLKKPGPPWAAFATDEYQWLQ IDLNKEKKITGIITTGSTMVEHNYYVSAYRILYSDDGQK WTVYREPGVEQDKIFQGNKDYHQDVRNNFLPPIIARFIR VNPTQWQQKIAMKMELLGCQFIPKGRPPKLTQPPPPRNS NDLKNTTAPPKIAKGRAPKFTQPLQPRSSNEFPAQTEQT TASPDIRNTTVTPNVTKDVALAAVLVPVLVMVLTTLILI LVCAWHWRNRKKKTEGTYDLPYWDRAGWWKGMKQFLPAK AVDHEETPVRYSSSEVNHLSPREVTTVLQADSAEYAQPL VGGIVGTLHQRSTFKPEEGKEAGYADLDPYNSPGQEVYH AYAEPLPITGPEYATPIIMDMSGHPTTSVGQPSTSTFKA TGNQPPPLVGTYNTLLSRTDSCSSAQAQYDTPKAGKPGL PAPDELVYQVPQSTQEVSGAGRDGECDVFKEIL

Database cross reference

RefSeq Protein accession:NP_563615
RefSeq Protein gi:54792129

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0009986;C:cell surface;IDA:UniProtKB. GO:0005887;C:integral to plasma membrane;IDA:UniProtKB.

GO-P

GO:0007155;P:cell adhesion;IEA:InterPro. GO:0030522;P:intracellular receptor mediated signaling pathway;NAS:UniProtKB. GO:0030308;P:negative regulation of cell growth;IDA:UniProtKB. GO:0042060;P:wound healing;IDA:UniProtKB.

Post-translational modification

LiverAtlas Protein ID

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr18202

PHOSPHORYLATION

606

S

Phospho-ELM

42021

HTP

N

HuLPr18202

PHOSPHORYLATION

724

S

Phospho-ELM

42022

HTP

N

HuLPr18202

PHOSPHORYLATION

715

Y

PhosphoSitePlus

455062

LTP

HTP

N

HuLPr18202

PHOSPHORYLATION

732

Y

PhosphoSitePlus

455063

LTP

N

HuLPr18202

PHOSPHORYLATION

649

Y

PhosphoSitePlus

473121

LTP

N

HuLPr18202

PHOSPHORYLATION

597

Y

PhosphoSitePlus

4033219

LTP

N

HuLPr18202

PHOSPHORYLATION

598

S

PhosphoSitePlus

4033223

LTP

N

HuLPr18202

PHOSPHORYLATION

663

Y

PhosphoSitePlus

3974132

LTP

N

HuLPr18202

PHOSPHORYLATION

134

Y

PhosphoSitePlus

1015883

HTP

N

HuLPr18202

PHOSPHORYLATION

621

Y

PhosphoSitePlus

454599

LTP

N

HuLPr18202

PHOSPHORYLATION

750

Y

PhosphoSitePlus

454600

LTP

N

HuLPr18202

PHOSPHORYLATION

565

Y

PhosphoSitePlus

458665

HTP

N

HuLPr18202

ACETYLATION

410

K

PhosphoSitePlus

14367104

LTP

N

HuLPr18202

PHOSPHORYLATION

734

T

PhosphoSitePlus

471773

LTP

N

HuLPr18202

PHOSPHORYLATION

655

Y

PhosphoSitePlus

478857

LTP

HTP

N

HuLPr18202

PHOSPHORYLATION

666

Y

PhosphoSitePlus

478858

LTP

HTP

N

HuLPr18202

PHOSPHORYLATION

600

S

PhosphoSitePlus

4149428

LTP

N

HuLPr18202

PHOSPHORYLATION

717

T

PhosphoSitePlus

4149432

LTP

N

HuLPr18202

PHOSPHORYLATION

606

S

PhosphoSitePlus

3209595

LTP

N