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Protein basic information

LiverAtlas Protein ID

HuLPr18317

Uniprot ID

DEN1C_HUMAN

Uniprot Acc

Q8IV53;B4E051;D3PFD4;Q8NDB1;Q9H5Z2;

Protein name

DENN domain-containing protein 1C

Comment

FUNCTION:Guanine nucleotide exchange factor (GEF) for RAB35.||SUBUNIT:Exhibits low nucleotide-independent RAB35-binding activity. Interacts with clathrin heavy chain/CLTC and with AP2A2, but not with AP2B1.||SUBCELLULAR LOCATION:Cytoplasm, cytosol (By similarity). Cytoplasmic vesicle, clathrin-coated vesicle (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8IV53-1; Sequence=Displayed; Name=2; IsoId=Q8IV53-2; Sequence=VSP 040669; Note=No experimental confirmation available;||SIMILARITY:Contains 1 dDENN domain.||SIMILARITY:Contains 1 DENN domain.||SIMILARITY:Contains 1 uDENN domain.||SEQUENCE CAUTION:Sequence=BAB15475.1; Type=Frameshift; Positions=788;

Subcellular localization

Cytoplasm, cytosol(By similarity).Cytoplasmic vesicle, clathrin-coated vesicle(By similarity).

Gene name

DENN/MADD domain containing 1C

Protein sequence

MESRAEGGSPAVFDWFFEAACPASLQEDPPILRQFPPDFR DQEAMQMVPKFCFPFDVEREPPSPAVQHFTFALTDLAGN RRFGFCRLRAGTQSCLCILSHLPWFEVFYKLLNTVGDLL AQDQVTEAEELLQNLFQQSLSGPQASVGLELGSGVTVSS GQGIPPPTRGNSKPLSCFVAPDSGRLPSIPENRNLTELV VAVTDENIVGLFAALLAERRVLLTASKLSTLTSCVHASC ALLYPMRWEHVLIPTLPPHLLDYCCAPMPYLIGVHASLA ERVREKALEDVVVLNVDANTLETTFNDVQALPPDVVSLL RLRLRKVALAPGEGVSRLFLKAQALLFGGYRDALVCSPG QPVTFSEEVFLAQKPGAPLQAFHRRAVHLQLFKQFIEAR LEKLNKGEGFSDQFEQEITGCGASSGALRSYQLWADNLK KGGGALLHSVKAKTQPAVKNMYRSAKSGLKGVQSLLMYK DGDSVLQRGGSLRAPALPSRSDRLQQRLPITQHFGKNRP LRPSRRRQLEEGTSEPPGAGTPPLSPEDEGCPWAEEALD SSFLGSGEELDLLSEILDSLSMGAKSAGSLRPSQSLDCC HRGDLDSCFSLPNIPRWQPDDKKLPEPEPQPLSLPSLQN ASSLDATSSSKDSRSQLIPSESDQEVTSPSQSSTASADP SIWGDPKPSPLTEPLILHLTPSHKAAEDSTAQENPTPWL STAPTEPSPPESPQILAPTKPNFDIAWTSQPLDPSSDPS SLEDPRARPPKALLAERAHLQPREEPGALNSPATPTSNC QKSQPSSRPRVADLKKCFEG

Database cross reference

RefSeq Protein accession:NP_079174
RefSeq Protein gi:113205087

Liver relevance

HLPP validation

Yes/No

Yes

Project name

French Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0030136;C:clathrin-coated vesicle;IEA:UniProtKB-SubCell. GO:0005829;C:cytosol;IEA:UniProtKB-SubCell.

GO-F

GO:0005085;F:guanyl-nucleotide exchange factor activity;IEA:UniProtKB-KW.

Post-translational modification

LiverAtlas Protein ID

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr18317

PHOSPHORYLATION

619

S

PhosphoSitePlus

14822418

LTP

N