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Protein basic information

LiverAtlas Protein ID

HuLPr18335

Uniprot ID

DERL2_HUMAN

Uniprot Acc

Q9GZP9;Q9Y3A7;

Protein name

Derlin-2

Comment

FUNCTION:Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal glycoproteins, but not that of misfolded nonglycoproteins. May act by forming a channel that allows the retrotranslocation of misfolded glycoproteins into the cytosol where they are ubiquitinated and degraded by the proteasome. May mediate the interaction between VCP and the degradation substrate. In contrast to DERL1, it is not involved in the degradation of MHC class I heavy chains following infection by cytomegaloviruses. May play a role in cell proliferation.||SUBUNIT:Forms homo- and heterooligomers with DERL3 and, to a lesser extent, with DERL1. Interacts with SELS, VCP and EDEM1. Mediates association between VCP and EDEM1, as well as that between VCP and the degradation substrate. Interacts with the SEL1L/SYVN1 and VCP/SELS protein complexes. Interacts with OS9.||SUBCELLULAR LOCATION:Endoplasmic reticulum membrane; Multi-pass membrane protein.||TISSUE SPECIFICITY:Ubiquitous.

Subcellular localization

Endoplasmic reticulum membrane;Multi-pass membrane protein.

Gene name

Der1-like domain family, member 2

Protein sequence

MAYQSLRLEYLQIPPVSRAYTTACVLTTAAVQLELITPFQ LYFNPELIFKHFQIWRLITNFLFFGPVGFNFLFNMIFLY RYCRMLEEGSFRGRTADFVFMFLFGGFLMTLFGLFVSLV FLGQAFTIMLVYVWSRRNPYVRMNFFGLLNFQAPFLPWV LMGFSLLLGNSIIVDLLGIAVGHIYFFLEDVFPNQPGGI RILKTPSILKAIFDTPDEDPNYNPLPEERPGGFAWGEGQRLGG

Database cross reference

RefSeq Protein accession:NP_057125
RefSeq Protein gi:31455614

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0030176;C:integral to endoplasmic reticulum membrane;IDA:UniProtKB.

GO-F

GO:0005515;F:protein binding;IPI:UniProtKB.

GO-P

GO:0030968;P:endoplasmic reticulum unfolded protein response;IDA:UniProtKB. GO:0030433;P:ER-associated protein catabolic process;IMP:UniProtKB. GO:0030307;P:positive regulation of cell growth;IDA:UniProtKB. GO:0008284;P:positive regulation of cell proli

Post-translational modification

LiverAtlas Protein ID

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr18335

PHOSPHORYLATION

218

Y

PhosphoSitePlus

458175

LTP

N