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Protein basic information

LiverAtlas Protein ID

HuLPr18351

Uniprot ID

DGAT2_HUMAN

Uniprot Acc

Q96PD7;A6ND76;Q5U810;Q68CL3;Q68DJ0;Q8NDB7;Q96BS0;Q9BYE5;

Protein name

Diacylglycerol O-acyltransferase 2

Comment

FUNCTION:Essential acyltransferase that catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. Required for synthesis and storage of intracellular triglycerides. Probably plays a central role in cytosolic lipid accumulation (By similarity).||CATALYTIC ACTIVITY:Acyl-CoA + 1,2-diacylglycerol = CoA + triacylglycerol.||ENZYME REGULATION:Inhibited by niacin (By similarity).||PATHWAY:Glycerolipid metabolism; triacylglycerol biosynthesis.||SUBCELLULAR LOCATION:Endoplasmic reticulum membrane; Multi-pass membrane protein.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q96PD7-1; Sequence=Displayed; Name=2; IsoId=Q96PD7-2; Sequence=VSP 020356;||TISSUE SPECIFICITY:Predominantly expressed in liver and white adipose tissue. Expressed at lower level in mammary gland, testis and peripheral blood leukocytes. Expressed in sebaceous glands of normal skin but decreased psoriatic skin.||SIM

Subcellular localization

Endoplasmic reticulum membrane;Multi-pass membrane protein.

Gene name

diacylglycerol O-acyltransferase 2

Protein sequence

MKTLIAAYSGVLRGERQAEADRSQRSHGGPALSREGSGRW GTGSSILSALQDLFSVTWLNRSKVEKQLQVISVLQWVLS FLVLGVACSAILMYIFCTDCWLIAVLYFTWLVFDWNTPK KGGRRSQWVRNWAVWRYFRDYFPIQLVKTHNLLTTRNYI FGYHPHGIMGLGAFCNFSTEATEVSKKFPGIRPYLATLA GNFRMPVLREYLMSGGICPVSRDTIDYLLSKNGSGNAII IVVGGAAESLSSMPGKNAVTLRNRKGFVKLALRHGADLV PIYSFGENEVYKQVIFEEGSWGRWVQKKFQKYIGFAPCI FHGRGLFSSDTWGLVPYSKPITTVVGEPITIPKLEHPTQ QDIDLYHTMYMEALVKLFDKHKTKFGLPETEVLEVN

Database cross reference

RefSeq Protein accession:NP_115953
RefSeq Protein gi:26024197

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

Ontology annotation

GO-C

GO:0005789;C:endoplasmic reticulum membrane;TAS:Reactome. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW.

GO-F

GO:0004144;F:diacylglycerol O-acyltransferase activity;IDA:UniProtKB.

GO-P

GO:0006071;P:glycerol metabolic process;IEA:UniProtKB-KW. GO:0019432;P:triglyceride biosynthetic process;IDA:UniProtKB.