Protein basic information
LiverAtlas Protein ID |
HuLPr18372 |
Uniprot ID |
|
Uniprot Acc |
Q53GQ0;A8K9B0;D3DR23;Q96JU2;Q9Y6G8; |
Protein name |
Estradiol 17-beta-dehydrogenase 12 |
Comment |
FUNCTION:Catalyzes the transformation of estrone (E1) into estradiol (E2), suggesting a central role in estrogen formation. Its strong expression in ovary and mammary gland suggest that it may constitute the major enzyme responsible for the conversion of E1 to E2 in women. Also has 3-ketoacyl-CoA reductase activity, reducing both long chain 3-ketoacyl-CoAs and long chain fatty acyl-CoAs, suggesting a role in long fatty acid elongation.||CATALYTIC ACTIVITY:Estradiol-17-beta + NAD(P)(+) = estrone + NAD(P)H.||BIOPHYSICOCHEMICAL PROPERTIES:Kinetic parameters: KM=3.5 uM for estrone;||PATHWAY:Steroid biosynthesis; estrogen biosynthesis.||PATHWAY:Lipid metabolism; fatty acid biosynthesis.||SUBUNIT:Interacts with ELOVL1 and LASS2.||SUBCELLULAR LOCATION:Endoplasmic reticulum membrane; Multi-pass membrane protein.||TISSUE SPECIFICITY:Expressed in most tissues tested. Highly expressed in the ovary and mammary. Expressed in platelets.||DOMAIN:The di-lysine motif confers endoplasmic reticulum loca |
Subcellular localization |
Endoplasmic reticulum membrane;Multi-pass membrane protein. |
Gene name |
|
Protein sequence
|
MESALPAAGFLYWVGAGTVAYLALRISYSLFTALRVWGVG NEAGVGPGLGEWAVVTGSTDGIGKSYAEELAKHGMKVVL ISRSKDKLDQVSSEIKEKFKVETRTIAVDFASEDIYDKI KTGLAGLEIGILVNNVGMSYEYPEYFLDVPDLDNVIKKM ININILSVCKMTQLVLPGMVERSKGAILNISSGSGMLPV PLLTIYSATKTFVDFFSQCLHEEYRSKGVFVQSVLPYFV ATKLAKIRKPTLDKPSPETFVKSAIKTVGLQSRTNGYLI HALMGSIISNLPSWIYLKIVMNMNKSTRAHYLKKTKKN |
Database cross reference |
RefSeq Protein accession:NP_057226
|
Liver relevance
HLPP validation |
Yes/No |
Yes |
Project name |
Chinese Liver;French Liver;Human Liver Organelles; |
Ontology annotation
GO-C |
GO:0005789;C:endoplasmic reticulum membrane;EXP:Reactome. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. |
GO-F |
GO:0004303;F:estradiol 17-beta-dehydrogenase activity;IEA:EC. GO:0016509;F:long-chain-3-hydroxyacyl-CoA dehydrogenase activity;EXP:Reactome. |
GO-P |
GO:0035338;P:long-chain fatty-acyl-CoA biosynthetic process;TAS:Reactome. GO:0055114;P:oxidation-reduction process;IEA:UniProtKB-KW. GO:0006694;P:steroid biosynthetic process;IEA:UniProtKB-KW. GO:0019432;P:triglyceride biosynthetic process;EXP:Reactome. |
Post-translational modification
LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
HuLPr18372 |
PHOSPHORYLATION |
164 |
S |
PhosphoSitePlus |
LTP |
N |
||
HuLPr18372 |
ACETYLATION |
117 |
K |
PhosphoSitePlus |
LTP |
N |