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Protein basic information

LiverAtlas Protein ID

HuLPr18372

Uniprot ID

DHB12_HUMAN

Uniprot Acc

Q53GQ0;A8K9B0;D3DR23;Q96JU2;Q9Y6G8;

Protein name

Estradiol 17-beta-dehydrogenase 12

Comment

FUNCTION:Catalyzes the transformation of estrone (E1) into estradiol (E2), suggesting a central role in estrogen formation. Its strong expression in ovary and mammary gland suggest that it may constitute the major enzyme responsible for the conversion of E1 to E2 in women. Also has 3-ketoacyl-CoA reductase activity, reducing both long chain 3-ketoacyl-CoAs and long chain fatty acyl-CoAs, suggesting a role in long fatty acid elongation.||CATALYTIC ACTIVITY:Estradiol-17-beta + NAD(P)(+) = estrone + NAD(P)H.||BIOPHYSICOCHEMICAL PROPERTIES:Kinetic parameters: KM=3.5 uM for estrone;||PATHWAY:Steroid biosynthesis; estrogen biosynthesis.||PATHWAY:Lipid metabolism; fatty acid biosynthesis.||SUBUNIT:Interacts with ELOVL1 and LASS2.||SUBCELLULAR LOCATION:Endoplasmic reticulum membrane; Multi-pass membrane protein.||TISSUE SPECIFICITY:Expressed in most tissues tested. Highly expressed in the ovary and mammary. Expressed in platelets.||DOMAIN:The di-lysine motif confers endoplasmic reticulum loca

Subcellular localization

Endoplasmic reticulum membrane;Multi-pass membrane protein.

Gene name

hydroxysteroid (17-beta) dehydrogenase 12

Protein sequence

MESALPAAGFLYWVGAGTVAYLALRISYSLFTALRVWGVG NEAGVGPGLGEWAVVTGSTDGIGKSYAEELAKHGMKVVL ISRSKDKLDQVSSEIKEKFKVETRTIAVDFASEDIYDKI KTGLAGLEIGILVNNVGMSYEYPEYFLDVPDLDNVIKKM ININILSVCKMTQLVLPGMVERSKGAILNISSGSGMLPV PLLTIYSATKTFVDFFSQCLHEEYRSKGVFVQSVLPYFV ATKLAKIRKPTLDKPSPETFVKSAIKTVGLQSRTNGYLI HALMGSIISNLPSWIYLKIVMNMNKSTRAHYLKKTKKN

Database cross reference

RefSeq Protein accession:NP_057226
RefSeq Protein gi:7705855

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005789;C:endoplasmic reticulum membrane;EXP:Reactome. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW.

GO-F

GO:0004303;F:estradiol 17-beta-dehydrogenase activity;IEA:EC. GO:0016509;F:long-chain-3-hydroxyacyl-CoA dehydrogenase activity;EXP:Reactome.

GO-P

GO:0035338;P:long-chain fatty-acyl-CoA biosynthetic process;TAS:Reactome. GO:0055114;P:oxidation-reduction process;IEA:UniProtKB-KW. GO:0006694;P:steroid biosynthetic process;IEA:UniProtKB-KW. GO:0019432;P:triglyceride biosynthetic process;EXP:Reactome.

Post-translational modification

LiverAtlas Protein ID

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr18372

PHOSPHORYLATION

164

S

PhosphoSitePlus

18010626

LTP

N

HuLPr18372

ACETYLATION

117

K

PhosphoSitePlus

1194754

LTP

N