HuLPr18399

Uniprot ID

DHRS9_HUMAN

Uniprot Acc

Q9BPW9;D3DPC1;Q5RKX1;Q9NRA9;Q9NRB0;

Protein name

Dehydrogenase/reductase SDR family member 9

Comment

FUNCTION:3-alpha-hydroxysteroid dehydrogenase that converts 3- alpha-tetrahydroprogesterone (allopregnanolone) to dihydroxyprogesterone and 3-alpha-androstanediol to dihydroxyprogesterone. May play a role in the biosynthesis of retinoic acid from retinaldehyde, but seems to have low activity with retinoids. Can utilize both NADH and NADPH.||BIOPHYSICOCHEMICAL PROPERTIES:Kinetic parameters: KM=9 uM for NADH; KM=72 uM for NAD; KM=5 uM for allopregnanolone; KM=7.5 uM for 3-alpha-androstanediol; KM=24 uM for androsterone; KM=12 uM for dihydrotestosterone;||SUBUNIT:Homotetramer (By similarity).||SUBCELLULAR LOCATION:Microsome membrane. Endoplasmic reticulum membrane (Potential). Note=Associated with microsomal membranes.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9BPW9-1; Sequence=Displayed; Name=2; Synonyms=Retinol dehydrogenase homolog isoform-2; IsoId=Q9BPW9-2; Sequence=VSP 015875; Note=No experimental confirmation available; Name=

Subcellular localization

Microsome membrane.Endoplasmic reticulum membrane(Potential).

Gene name

dehydrogenase/reductase (SDR family) member 9

Protein sequence

MLFWVLGLLILCGFLWTRKGKLKIEDITDKYIFITGCDSG FGNLAARTFDKKGFHVIAACLTESGSTALKAETSERLRT VLLDVTDPENVKRTAQWVKNQVGEKGLWGLINNAGVPGV LAPTDWLTLEDYREPIEVNLFGLISVTLNMLPLVKKAQG RVINVSSVGGRLAIVGGGYTPSKYAVEGFNDSLRRDMKA FGVHVSCIEPGLFKTNLADPVKVIEKKLAIWEQLSPDIK QQYGEGYIEKSLDKLKGNKSYVNMDLSPVVECMDHALTS LFPKTHYAAGKDAKIFWIPLSHMPAALQDFLLLKQKAELANPKAV

Database cross reference

RefSeq Protein accession:NP_001135742
RefSeq Protein gi:214010156

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

GO:0030176;C:integral to endoplasmic reticulum membrane;IDA:UniProtKB. GO:0005792;C:microsome;IDA:UniProtKB.

GO-F

GO:0004022;F:alcohol dehydrogenase (NAD) activity;IDA:UniProtKB. GO:0005488;F:binding;IEA:InterPro. GO:0016854;F:racemase and epimerase activity;NAS:UniProtKB. GO:0004745;F:retinol dehydrogenase activity;IDA:UniProtKB. GO:0047035;F:testosterone dehydro

GO-P

GO:0042904;P:9-cis-retinoic acid biosynthetic process;IDA:UniProtKB. GO:0008209;P:androgen metabolic process;IDA:UniProtKB. GO:0030855;P:epithelial cell differentiation;NAS:UniProtKB. GO:0055114;P:oxidation-reduction process;IEA:UniProtKB-KW. GO:004244

Retinol_Metabolism