HuLPr18557

Uniprot ID

DNS2B_HUMAN

Uniprot Acc

Q8WZ79;Q5VXD0;Q5VXD1;Q8WZ80;Q9NQW3;

Protein name

Deoxyribonuclease-2-beta

Comment

FUNCTION:Hydrolyzes DNA under acidic conditions. Does not require divalent cations for activity. Participates in the degradation of nuclear DNA during lens cell differentiation.||CATALYTIC ACTIVITY:Endonucleolytic cleavage to nucleoside 3'- phosphates and 3'-phosphooligonucleotide end-products.||SUBCELLULAR LOCATION:Lysosome (Probable).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q8WZ79-1; Sequence=Displayed; Name=2; IsoId=Q8WZ79-2; Sequence=VSP 009812;||TISSUE SPECIFICITY:Highly expressed in the eye lens and in salivary gland. Detected at lower levels in lung, prostate and lymph node. Isoform 2 is lung specific.||SIMILARITY:Belongs to the DNase II family.||SEQUENCE CAUTION:Sequence=AAF76893.1; Type=Erroneous initiation;

Subcellular localization

Lysosome(Probable).

Gene name

deoxyribonuclease II beta

Protein sequence

MKQKMMARLLRTSFALLFLGLFGVLGAATISCRNEEGKAV DWFTFYKLPKRQNKESGETGLEYLYLDSTTRSWRKSEQL MNDTKSVLGRTLQQLYEAYASKSNNTAYLIYNDGVPKPV NYSRKYGHTKGLLLWNRVQGFWLIHSIPQFPPIPEEGYD YPPTGRRNGQSGICITFKYNQYEAIDSQLLVCNPNVYSC SIPATFHQELIHMPQLCTRASSSEIPGRLLTTLQSAQGQ KFLHFAKSDSFLDDIFAAWMAQRLKTHLLTETWQRKRQE LPSNCSLPYHVYNIKAIKLSRHSYFSSYQDHAKWCISQK GTKNRWTCIGDLNRSPHQAFRSGGFICTQNWQIYQAFQG LVLYYESCK

Database cross reference

RefSeq Protein accession:NP_067056
RefSeq Protein gi:194473657

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;

GO:0005764;C:lysosome;IEA:UniProtKB-SubCell.

GO-F

GO:0004531;F:deoxyribonuclease II activity;IEA:EC.

GO-P

GO:0006259;P:DNA metabolic process;IEA:InterPro.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr18557

PHOSPHORYLATION

283

Y

PhosphoSitePlus

1029145

LTP

HTP

N

HuLPr18557

PHOSPHORYLATION

286

Y

PhosphoSitePlus

1029149

LTP

HTP

N