Protein basic information
| LiverAtlas Protein ID |
HuLPr18564 |
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Uniprot ID |
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Uniprot Acc |
Q5JSL3;A6NMF0;Q66M66;Q6ZUJ5;Q86VU8;Q96MN3; |
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Protein name |
Dedicator of cytokinesis protein 11 |
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Comment |
FUNCTION:Guanine nucleotide-exchange factor (GEF) that activates CDC42 by exchanging bound GDP for free GTP (By similarity).||SUBUNIT:Interacts with CDC42 (By similarity).||DOMAIN:The DHR-2 domain is necessary for the GEF activity (By similarity).||PTM:Phosphorylated upon DNA damage, probably by ATM or ATR.||MISCELLANEOUS:'Zizim' means 'spike' in Hebrew.||SIMILARITY:Belongs to the DOCK family.||SIMILARITY:Contains 1 DHR-1 (CZH-1) domain.||SIMILARITY:Contains 1 DHR-2 (CZH-2) domain.||SIMILARITY:Contains 1 PH domain.||SEQUENCE CAUTION:Sequence=BAB71253.1; Type=Erroneous initiation; Sequence=BAC86230.1; Type=Erroneous initiation; Sequence=CAI41407.1; Type=Erroneous gene model prediction; Sequence=CAI41411.1; Type=Erroneous gene model prediction; |
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Gene name |
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Protein sequence
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MAEVRKFTKRLSKPGTAAELRQSVSEAVRGSVVLEKAKVV EPLDYENVIAQRKTQIYSDPLRDLLMFPMEDISISVIGR QRRTVQSTVPEDAEKRAQSLFVKECIKTYSTDWHVVNYK YEDFSGDFRMLPCKSLRPEKIPNHVFEIDEDCEKDEDSS SLCSQKGGVIKQGWLHKANVNSTITVTMKVFKRRYFYLT QLPDGSYILNSYKDEKNSKESKGCIYLDACIDVVQCPKM RRHAFELKMLDKYSHYLAAETEQEMEEWLITLKKIIQIN TDSLVQEKKETVETAQDDETSSQGKAENIMASLERSMHP ELMKYGRETEQLNKLSRGDGRQNLFSFDSEVQRLDFSGI EPDIKPFEEKCNKRFLVNCHDLTFNILGQIGDNAKGPPT NVEPFFINLALFDVKNNCKISADFHVDLNPPSVREMLWG SSTQLASDGSPKGSSPESYIHGIAESQLRYIQQGIFSVT NPHPEIFLVARIEKVLQGNITHCAEPYIKNSDPVKTAQK VHRTAKQVCSRLGQYRMPFAWAARPIFKDTQGSLDLDGR FSPLYKQDSSKLSSEDILKLLSEYKKPEKTKLQIIPGQL NITVECVPVDLSNCITSSYVPLKPFEKNCQNITVEVEEF VPEMTKYCYPFTIYKNHLYVYPLQLKYDSQKTFAKARNI AVCVEFRDSDESDASALKCIYGKPAGSVFTTNAYAVVSH HNQNPEFYDEIKIELPIHLHQKHHLLFTFYHVSCEINTK GTTKKQDTVETPVGFAWVPLLKDGRIITFEQQLPVSANL PPGYLNLNDAESRRQCNVDIKWVDGAKPLLKIKSHLEST IYTQDLHVHKFFHHCQLIQSGSKEVPGELIKYLKCLHAM EIQVMIQFLPVILMQLFRVLTNMTHEDDVPINCTMVLLH IVSKCHEEGLDSYLRSFIKYSFRPEKPSAPQAQLIHETL ATTMIAILKQSADFLSINKLLKYSWFFFEIIAKSMATYL LEENKIKLPRGQRFPETYHHVLHS |
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Database cross reference |
RefSeq Protein accession:NP_653259
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
French Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005829;C:cytosol;TAS:Reactome. |
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GO-F |
GO:0005525;F:GTP binding;IEA:InterPro. |
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GO-P |
GO:0007596;P:blood coagulation;TAS:Reactome. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr18564 |
PHOSPHORYLATION |
158 |
S |
Phospho-ELM |
HTP |
N |
 
|
|
|
HuLPr18564 |
PHOSPHORYLATION |
161 |
S |
Phospho-ELM |
HTP |
N |
|
|
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HuLPr18564 |
PHOSPHORYLATION |
1636 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
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HuLPr18564 |
PHOSPHORYLATION |
87 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr18564 |
PHOSPHORYLATION |
98 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr18564 |
PHOSPHORYLATION |
57 |
Y |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr18564 |
PHOSPHORYLATION |
1223 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr18564 |
PHOSPHORYLATION |
83 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr18564 |
PHOSPHORYLATION |
86 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr18564 |
PHOSPHORYLATION |
248 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
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HuLPr18564 |
PHOSPHORYLATION |
249 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
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HuLPr18564 |
PHOSPHORYLATION |
251 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
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HuLPr18564 |
PHOSPHORYLATION |
266 |
T |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr18564 |
PHOSPHORYLATION |
440 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr18564 |
PHOSPHORYLATION |
1029 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr18564 |
PHOSPHORYLATION |
1712 |
Y |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr18564 |
PHOSPHORYLATION |
12 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
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HuLPr18564 |
PHOSPHORYLATION |
1237 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
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HuLPr18564 |
PHOSPHORYLATION |
158 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr18564 |
PHOSPHORYLATION |
161 |
S |
PhosphoSitePlus |
LTP |
N |
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Pathway
| Pathway name |
