Protein basic information
| LiverAtlas Protein ID |
HuLPr18642 |
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Uniprot ID |
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Uniprot Acc |
Q8TB45;B2RCL9;Q96EQ1;Q9H0R7;Q9H894;Q9HA07; |
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Protein name |
DEP domain-containing mTOR-interacting protein |
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Comment |
FUNCTION:Negative regulator of the mTORC1 and mTORC2 signaling pathways. Inhibits the kinase activity of both complexes.||SUBUNIT:Interacts (via PDZ domain) with MTOR; interacts with MTOR within both mammalian target of rapamycin complexes mTORC1 and mTORC2.||INTERACTION:P42345:MTOR; NbExp=2; IntAct=EBI-2359040, EBI-359260; P42346:Mtor (xeno); NbExp=1; IntAct=EBI-2359040, EBI-1571489;||INDUCTION:Expression is negatively regulated by both mTORC1 and mTORC2 (at protein level).||PTM:Phosphorylated. Phosphorylation weakens interaction with MTOR within mTORC1 and mTORC2.||SIMILARITY:Contains 2 DEP domains.||SIMILARITY:Contains 1 PDZ (DHR) domain.||SEQUENCE CAUTION:Sequence=BAB14723.1; Type=Erroneous initiation; Note=Translation N-terminally extended; |
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Gene name |
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Protein sequence
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MEEGGSTGSAGSDSSTSGSGGAQQRELERMAEVLVTGEQL RLRLHEEKVIKDRRHHLKTYPNCFVAKELIDWLIEHKEA SDRETAIKLMQKLADRGIIHHVCDEHKEFKDVKLFYRFR KDDGTFPLDNEVKAFMRGQRLYEKLMSPENTLLQPREEE GVKYERTFMASEFLDWLVQEGEATTRKEAEQLCHRLMEH GIIQHVSNKHPFVDSNLLYQFRMNFRRRRRLMELLNEKS PSSQETHDSPFCLRKQSHDNRKSTSFMSVSPSKEIKIVS AVRRSSMSSCGSSGYFSSSPTLSSSPPVLCNPKSVLKRP VTSEELLTPGAPYARKTFTIVGDAVGWGFVVRGSKPCHI QAVDPSGPAAAAGMKVCQFVVSVNGLNVLHVDYRTVSNL ILTGPRTIVMEVMEELEC |
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Database cross reference |
RefSeq Protein accession:NP_073620
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver; |
Ontology annotation
| GO-C |
GO:0005622;C:intracellular;IDA:LIFEdb. |
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GO-F |
GO:0005515;F:protein binding;IPI:UniProtKB. |
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GO-P |
GO:0035556;P:intracellular signal transduction;IEA:InterPro. GO:0045792;P:negative regulation of cell size;IMP:UniProtKB. GO:0006469;P:negative regulation of protein kinase activity;IMP:UniProtKB. GO:0032007;P:negative regulation of TOR signaling cascad |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr18642 |
PHOSPHORYLATION |
9 |
S |
PhosphoSitePlus |
LTP |
N |
 
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|
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HuLPr18642 |
PHOSPHORYLATION |
265 |
S |
PhosphoSitePlus |
LTP HTP |
N |
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Pathway
| Pathway name |
Signaling_events_mediated_by_Hepatocyte_Growth_Factor_Receptor_(c-Met) |
| Pathway name |
