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Protein basic information

LiverAtlas Protein ID

HuLPr18661

Uniprot ID

DRB4_HUMAN

Uniprot Acc

P13762;B0S863;O78042;P79664;Q29889;Q30163;Q6TLK6;Q860N4;Q861F3;Q8WLT9;Q9BS54;

Protein name

HLA class II histocompatibility antigen, DR beta 4 chain

Comment

FUNCTION:Binds peptides derived from antigens that access the endocytic route of antigen presenting cells (APC) and presents them on the cell surface for recognition by the CD4 T-cells. The peptide binding cleft accomodates peptides of 10-30 residues. The peptides presented by MHC class II molecules are generated mostly by degradation of proteins that access the endocytic route, where they are processed by lysosomal proteases and other hydrolases. Exogenous antigens that have been endocytosed by the APC are thus readily available for presentation via MHC II molecules, and for this reason this antigen presentation pathway is usually referred to as exogenous. As membrane proteins on their way to degradation in lysosomes as part of their normal turn-over are also contained in the endosomal/lysosomal compartments, exogenous antigens must compete with those derived from endogenous components. Autophagy is also a source of endogenous peptides, autophagosomes constitutively fuse with MHC clas

Subcellular localization

Cell membrane;Single-pass type I membrane protein.Endoplasmic reticulum membrane;Single-pass type I membrane protein.Golgi apparatus, trans-Golgi network membrane;Single-pass type I membrane protein.Endosome membrane;Single- pass type I membrane protein.Lysosome membrane;Single-pass type I membrane protein.Late endosome membrane;Single-pass type I membrane protein.

Gene name

major histocompatibility complex, class II, DR beta 4

Protein sequence

MVCLKLPGGSCMAALTVTLTVLSSPLALAGDTQPRFLEQA KCECHFLNGTERVWNLIRYIYNQEEYARYNSDLGEYQAV TELGRPDAEYWNSQKDLLERRRAEVDTYCRYNYGVVESF TVQRRVQPKVTVYPSKTQPLQHHNLLVCSVNGFYPGSIE VRWFRNGQEEKAGVVSTGLIQNGDWTFQTLVMLETVPRS GEVYTCQVEHPSMMSPLTVQWSARSESAQSKMLSGVGGF VLGLLFLGTGLFIYFRNQKGHSGLQPTGLLS

Database cross reference

RefSeq Protein accession:NP_068818
RefSeq Protein gi:52630344

Liver relevance

HLPP validation

Yes/No

Yes

Project name

French Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005789;C:endoplasmic reticulum membrane;IEA:UniProtKB-SubCell. GO:0005794;C:Golgi apparatus;IEA:UniProtKB-SubCell. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0031902;C:late endosome membrane;IDA:UniProtKB. GO:0005765;C:lysosomal membran

GO-P

GO:0002504;P:antigen processing and presentation of peptide or polysaccharide antigen via MHC class II;IEA:UniProtKB-KW. GO:0060333;P:interferon-gamma-mediated signaling pathway;TAS:Reactome. GO:0031295;P:T cell costimulation;TAS:Reactome. GO:0050852;P: