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Protein basic information

LiverAtlas Protein ID

HuLPr18705

Uniprot ID

DTX4_HUMAN

Uniprot Acc

Q9Y2E6;Q0VF38;

Protein name

Protein deltex-4

Comment

FUNCTION:Regulator of Notch signaling, a signaling pathway involved in cell-cell communications that regulates a broad spectrum of cell-fate determinations (By similarity).||SUBCELLULAR LOCATION:Cytoplasm (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9Y2E6-1; Sequence=Displayed; Name=2; IsoId=Q9Y2E6-2; Sequence=VSP 023784;||DOMAIN:The WWE domains are thought to mediate some protein- protein interaction, and are frequently found in ubiquitin ligases (By similarity).||SIMILARITY:Belongs to the Deltex family.||SIMILARITY:Contains 1 RING-type zinc finger.||SIMILARITY:Contains 2 WWE domains.||SEQUENCE CAUTION:Sequence=BAA76781.1; Type=Erroneous initiation;

Subcellular localization

Cytoplasm(By similarity).

Gene name

deltex homolog 4 (Drosophila)

Protein sequence

MLLASAVVVWEWLNEHGRWRPYSPAVSHHIEAVVRAGPRA GGSVVLGQVDSRLAPYIIDLQSMNQFRQDTGTLRPVRRN YYDPSSAPGKGVVWEWENDNGSWTPYDMEVGITIQHAYE KQHPWIDLTSIGFSYVIDFNTMGQINRQTQRQRRVRRRL DLIYPMVTGTLPKAQSWPVSPGPATSPPMSPCSCPQCVL VMSVKAAVVNGSTGPLQLPVTRKNMPPPGVVKLPPLPGS GAKPLDSTGTIRGPLKTAPSQVIRRQASSMPTGTTMGSP ASPPGPNSKTGRVALATLNRTNLQRLAIAQSRVLIASGV PTVPVKNLNGSSPVNPALAGITGILMSAAGLPVCLTRPP KLVLHPPPVSKSEIKSIPGVSNTSRKTTKKQAKKGKTPE EVLKKYLQKVRHPPDEDCTICMERLTAPSGYKGPQPTVK PDLVGKLSRCGHVYHIYCLVAMYNNGNKDGSLQCPTCKT IYGVKTGTQPPGKMEYHLIPHSLPGHPDCKTIRIIYSIP PGIQGPEHPNPGKSFSARGFPRHCYLPDSEKGRKVLKLL LVAWDRRLIFAIGTSSTTGESDTVIWNEVHHKTEFGSNL TGHGYPDANYLDNVLAELAAQGISEDSTAQEKD

Database cross reference

RefSeq Protein accession:NP_055992
RefSeq Protein gi:148237498

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005737;C:cytoplasm;IEA:UniProtKB-SubCell.

GO-F

GO:0008270;F:zinc ion binding;IEA:InterPro.

GO-P

GO:0007219;P:Notch signaling pathway;IEA:UniProtKB-KW.

Post-translational modification

LiverAtlas Protein ID

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr18705

PHOSPHORYLATION

376

S

PhosphoSitePlus

2527048

LTP

N

Pathway

Pathway name

Notch_signaling_pathway