HuLPr18707

Uniprot ID

DUOX1_HUMAN

Uniprot Acc

Q9NRD9;A6NH28;Q14C94;Q6ZMB3;Q6ZR09;Q9NZC1;

Protein name

Dual oxidase 1

Comment

FUNCTION:Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.||CATALYTIC ACTIVITY:NAD(P)H + O(2) = NAD(P)(+) + H(2)O(2).||ENZYME REGULATION:The NADPH oxidase activity is calcium- dependent. Peroxidase activity is inhibited by aminobenzohydrazide.||PATHWAY:Hormone biosynthesis; thyroid hormone biosynthesis.||SUBUNIT:Interacts with TXNDC11, TPO and CYBA.||SUBCELLULAR LOCATION:Apical cell membrane; Multi-pass membrane protein. Note=Localizes to the apical membrane of epithelial cells.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9NRD9-1; Sequence=Displayed; Name=2; IsoId=Q9NRD9-2; Sequence=VSP 017262, VSP 017263; Note=No experimental confirmation available;||TISSUE SPECIFICITY:Expresse

Subcellular localization

Apical cell membrane;Multi-pass membrane protein.

Gene name

dual oxidase 1

Protein sequence

MGFCLALAWTLLVGAWTPLGAQNPISWEVQRFDGWYNNLM EHRWGSKGSRLQRLVPASYADGVYQPLGEPHLPNPRDLS NTISRGPAGLASLRNRTVLGVFFGYHVLSDLVSVETPGC PAEFLNIRIPPGDPMFDPDQRGDVVLPFQRSRWDPETGR SPSNPRDPANQVTGWLDGSAIYGSSHSWSDALRSFSRGQ LASGPDPAFPRDSQNPLLMWAAPDPATGQNGPRGLYAFG AERGNREPFLQALGLLWFRYHNLWAQRLARQHPDWEDEE LFQHARKRVIATYQNIAVYEWLPSFLQKTLPEYTGYRPF LDPSISSEFVAASEQFLSTMVPPGVYMRNASCHFQGVIN RNSSVSRALRVCNSYWSREHPSLQSAEDVDALLLGMASQ IAEREDHVLVEDVRDFWPGPLKFSRTDHLASCLQRGRDL GLPSYTKARAALGLSPITRWQDINPALSRSNDTVLEATA ALYNQDLSWLELLPGGLLESHRDPGPLFSTIVLEQFVRL RDGDRYWFENTRNGLFSKKEIEEIRNTTLQDVLVAVINI DPSALQPNVFVWHKGDPCPQPRQLSTEGLPACAPSVVRD YFEGSGFGFGVTIGTLCCFPLVSLLSAWIVARLRMRNFK RLQGQDRQSIVSEKLVGGMEALEWQGHKEPCRPVLVYLQ PGQIRVVDGRLTVLRTIQLQPPQKVNFVLSSNRGRRTLL LKIPKEYDLVLLFNLEEERQALVENLRGALKESGLSIQE WELREQELMRAAVTREQRRHLLETFFRHLFSQVLDINQA DAGTLPLDSSQKVREALTCELSRAEFAESLGLKPQDMFV ESMFSLADKDGNGYLSFREFLDILVVFMKGSPEEKSRLM FRMYDFDGNGLISKDEFIRMLRSFIEISNNCLSKAQLAE VVESMFRESGFQDKEELTWEDFHFMLRDHNSELRFTQLC VKGVEVPEVIKDLCRRASYISQDMICPSPRVSARCSRSD IETELTPQRLQCPMDTDPPQEIRR

Database cross reference

RefSeq Protein accession:NP_059130
RefSeq Protein gi:20149640

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Fetal Liver;Human Liver Organelles;

GO:0016324;C:apical plasma membrane;NAS:UniProtKB. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW.

GO-F

GO:0005509;F:calcium ion binding;IEA:InterPro. GO:0009055;F:electron carrier activity;IEA:InterPro. GO:0050660;F:flavin adenine dinucleotide binding;IEA:InterPro. GO:0020037;F:heme binding;IEA:InterPro. GO:0016174;F:NAD(P)H oxidase activity;NAS:UniProt

GO-P

GO:0042335;P:cuticle development;IMP:UniProtKB. GO:0019221;P:cytokine-mediated signaling pathway;IDA:UniProtKB. GO:0042446;P:hormone biosynthetic process;IEA:UniProtKB-KW. GO:0050665;P:hydrogen peroxide biosynthetic process;NAS:UniProtKB. GO:0042744;P:

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr18707

PHOSPHORYLATION

1217

S

PhosphoSitePlus

6370300

LTP

HTP

N

HuLPr18707

PHOSPHORYLATION

955

S

PhosphoSitePlus

6370301

LTP

N

HuLPr18707

PHOSPHORYLATION

1008

S

PhosphoSitePlus

3072831

LTP

N

Tyrosine_Metabolism