Protein basic information
| LiverAtlas Protein ID |
HuLPr18708 |
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Uniprot ID |
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Uniprot Acc |
Q9NRD8;A8MQ13;Q9NR02;Q9UHF9; |
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Protein name |
Dual oxidase 2 |
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Comment |
FUNCTION:Generates hydrogen peroxide which is required for the activity of thyroid peroxidase/TPO and lactoperoxidase/LPO. Plays a role in thyroid hormones synthesis and lactoperoxidase-mediated antimicrobial defense at the surface of mucosa. May have its own peroxidase activity through its N-terminal peroxidase-like domain.||CATALYTIC ACTIVITY:NAD(P)H + O(2) = NAD(P)(+) + H(2)O(2).||ENZYME REGULATION:Peroxidase activity is inhibited by aminobenzohydrazide (By similarity). The NADPH oxidase activity is calcium-dependent.||PATHWAY:Hormone biosynthesis; thyroid hormone biosynthesis.||SUBUNIT:Interacts with TXNDC11, TPO and CYBA.||SUBCELLULAR LOCATION:Apical cell membrane; Multi-pass membrane protein. Note=Localizes to the apical membrane of epithelial cells.||TISSUE SPECIFICITY:Expressed in colon, small intestine, duodenum and tracheal surface epithelial cells (at protein level). Expressed in thyrocytes. Also detected in kidney, liver, lung, pancreas, prostate, salivary glands, rectum an |
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Subcellular localization |
Apical cell membrane;Multi-pass membrane protein. |
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Gene name |
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Protein sequence
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MLRARPEALMLLGALLTGSLGPSGNQDALSLPWEVQRYDG WFNNLRHHERGAVGCRLQRRVPANYADGVYQALEEPQLP NPRRLSNAATRGIAGLPSLHNRTVLGVFFGYHVLSDVVS VETPGCPAEFLNIRIPPGDPVFDPDQRGDVVLPFQRSRW DPETGRSPSNPRDLANQVTGWLDGSAIYGSSHSWSDALR SFSGGQLASGPDPAFPRDSQNPLLMWAAPDPATGQNGPR GLYAFGAERGNREPFLQALGLLWFRYHNLWAQRLARQHP DWEDEELFQHARKRVIATYQNIAVYEWLPSFLQKTLPEY TGYRPFLDPSISPEFVVASEQFFSTMVPPGVYMRNASCH FRKVLNKGFQSSQALRVCNNYWIRENPNLNSTQEVNELL LGMASQISELEDNIVVEDLRDYWPGPGKFSRTDYVASSI QRGRDMGLPSYSQALLAFGLDIPRNWSDLNPNVDPQVLE ATAALYNQDLSQLELLLGGLLESHGDPGPLFSAIVLDQF VRLRDGDRYWFENTRNGLFSKKEIEDIRNTTLRDVLVAV INIDPSALQPNVFVWHKGAPCPQPKQLTTDGLPQCAPLT VLDFFEGSSPGFAITIIALCCLPLVSLLLSGVVAYFRGR EHKKLQKKLKESVKKEAAKDGVPAMEWPGPKERSSPIII QLLSDRCLQVLNRHLTVLRVVQLQPLQQVNLILSNNRGC RTLLLKIPKEYDLVLLFSSEEERGAFVQQLWDFCVRWAL GLHVAEMSEKELFRKAVTKQQRERILEIFFRHLFAQVLD INQADAGTLPLDSSQKVREALTCELSRAEFAESLGLKPQ DMFVESMFSLADKDGNGYLSFREFLDILVVFMKGSPEDK SRLMFTMYDLDENGFLSKDEFFTMMRSFIEISNNCLSKA QLAEVVESMFRESGFQDKEELTWEDFHFMLRDHDSELRF TQLCVKGGGGGGNGIRDIFKQNISCRVSFITRTPGERSH PQGLGPPAPEAPELGGPGLKKRFG |
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Database cross reference |
RefSeq Protein accession:NP_054799
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Liver relevance
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0016324;C:apical plasma membrane;IEA:UniProtKB-SubCell. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. |
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GO-F |
GO:0005509;F:calcium ion binding;IDA:UniProtKB. GO:0009055;F:electron carrier activity;IEA:InterPro. GO:0050660;F:flavin adenine dinucleotide binding;IEA:InterPro. GO:0020037;F:heme binding;IEA:InterPro. GO:0016174;F:NAD(P)H oxidase activity;IDA:UniPro |
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GO-P |
GO:0042335;P:cuticle development;ISS:UniProtKB. GO:0019221;P:cytokine-mediated signaling pathway;IDA:UniProtKB. GO:0042446;P:hormone biosynthetic process;IEA:UniProtKB-KW. GO:0042744;P:hydrogen peroxide catabolic process;IEA:UniProtKB-KW. GO:0051591;P: |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
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HuLPr18708 |
PHOSPHORYLATION |
1007 |
T |
PhosphoSitePlus |
LTP |
N |
 
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HuLPr18708 |
PHOSPHORYLATION |
1012 |
T |
PhosphoSitePlus |
LTP |
N |
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Pathway
| Pathway name |
