HuLPr18725

Uniprot ID

DUS26_HUMAN

Uniprot Acc

Q9BV47;D3DSV8;Q9BTW0;

Protein name

Dual specificity protein phosphatase 26

Comment

FUNCTION:Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. Inhibits MAP kinase p38 by dephosphorylating it and inhibits p38-mediated apoptosis in anaplastic thyroid cancer cells. Can also induce activation of MAP kinase p38 and c-Jun N-terminal kinase (JNK).||CATALYTIC ACTIVITY:Protein tyrosine phosphate + H(2)O = protein tyrosine + phosphate.||CATALYTIC ACTIVITY:A phosphoprotein + H(2)O = a protein + phosphate.||SUBUNIT:Interacts with HSF4.||INTERACTION:P04637:TP53; NbExp=6; IntAct=EBI-2924519, EBI-366083;||SUBCELLULAR LOCATION:Cytoplasm. Nucleus. Golgi apparatus.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9BV47-1; Sequence=Displayed; Name=2; IsoId=Q9BV47-2; Sequence=VSP 026406;||TISSUE SPECIFICITY:Brain. In the brain it is expressed ubiquitously except in the hippocampus. Expressed in embryonal cancers (retinoblastoma, neuroepithilioma and neuroblastoma)

Subcellular localization

Cytoplasm.Nucleus.Golgi apparatus.

Gene name

dual specificity phosphatase 26 (putative)

Protein sequence

MCPGNWLWASMTFMARFSRSSSRSPVRTRGTLEEMPTVQH PFLNVFELERLLYTGKTACNHADEVWPGLYLGDQDMANN RRELRRLGITHVLNASHSRWRGTPEAYEGLGIRYLGVEA HDSPAFDMSIHFQTAADFIHRALSQPGGKILVHCAVGVS RSATLVLAYLMLYHHLTLVEAIKKVKDHRGIIPNRGFLR QLLALDRRLRQGLEA

Database cross reference

RefSeq Protein accession:NP_076930
RefSeq Protein gi:13128968

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

GO:0005794;C:Golgi apparatus;IEA:UniProtKB-SubCell. GO:0005634;C:nucleus;IEA:UniProtKB-SubCell.

GO-F

GO:0005515;F:protein binding;IPI:IntAct. GO:0004725;F:protein tyrosine phosphatase activity;IEA:EC. GO:0008138;F:protein tyrosine/serine/threonine phosphatase activity;ISS:RefGenome.