Protein basic information
| LiverAtlas Protein ID |
HuLPr18759 |
|
Uniprot ID |
|
|
Uniprot Acc |
Q96JB1;O00438;Q5JYI2;Q5T2M3;Q5T2M4;Q5TG00;Q9UEM4; |
|
Protein name |
Dynein heavy chain 8, axonemal |
|
Comment |
FUNCTION:Force generating protein of respiratory cilia. Produces force towards the minus ends of microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Involved in sperm motility; implicated in sperm flagellar assembly (By similarity).||SUBUNIT:Consists of at least two heavy chains and a number of intermediate and light chains.||SUBCELLULAR LOCATION:Cytoplasm, cytoskeleton, cilium axoneme (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q96JB1-1; Sequence=Displayed; Name=2; IsoId=Q96JB1-2; Sequence=VSP 022614; Name=3; IsoId=Q96JB1-3; Sequence=Not described; Name=4; IsoId=Q96JB1-4; Sequence=Not described;||DOMAIN:Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly- linked AAA domains in the head, which form a ring. A stalk-like structure (fo |
|
Subcellular localization |
Cytoplasm, cytoskeleton, cilium axoneme(By similarity). |
|
Gene name |
|
|
Protein sequence
|
MMKLYIDNAAPDKLKGLCIFFVRCRNDVAINVKTIQEEAL FTVLDASKGLLNGIRDMLANIFLPAVLATNNWGALNQSK QGESEKHIFTETINRYLSFLDGARISIEGTVKLKTIDNV NFSKLHTFEEVTAAASNSETVHQLEEVLMVWYKQIEQVL IESEQMRKEAGDSGPLTELEHWKRMSAKFNYIIEQIKGP SCKAVINVLNVAHSKLLKNWRDLDARITDTANESKDNVR YLYTLEKVCQPLYNHDLVSMAHGIQNLINAIRMIHGVSR YYNTSERMTSLFIKVTNQMVTACKAYITDGGLNHVWDQE TPVVLKKIQDCIFLFKEYQASFHKTRKLISESSGEKSFE VSEMYIFGKFEAFCKRLEKITEMITVVQTYSTLSNSTIE GIDIMAIKFRNIYQGVKKKQYDILDPRRTEFDTDFLDFM TKINGLEVQIQAFMNSSFGKILSSQQALQLLQRFQKLNI PCLGLEINHTIERILQYYVAELDATKKLYHSQKDDPPLA RNMPPIAGKILWVRQLYRRISEPINYFFKNSDILSSPDG KAVIRQYNKISYVLVEFEVVYHTAWIREISQLHYALQAT LFVRHPETGKLLVNFDPKILEVVRETKCMIKMKLDVPEQ AKRLLKLESKLKADKLYLQGLLQYYDELCQEVPSVFVNL MTPKMKKVESVLRQGLTVLTWSSLTLESFFQEVELVLDM FNQLLKKISDLCEMHIDTVLKEIAKTVLISLPESGATKV EDMLTLNETYTKEWADILNHKSKHVEEAVRELISIFEQI YEVKYTGKVGKQSEQRKHVVFGSETGEGENNDYEANIVN EFDTHDKEDEFKKECKEVFAFFSHQLLDSLQKATRLSLD TMKRRIFVASLYGRKQSEDIISFIKSEVHLAIPNVVMIP SLDDIQQAINRMIQLTLEVSRGVAHWGQQQIRPIKSVIP SPTTTDVTHQNTGKLLKKEERSFEEAIPARKLKNFYPGV AEHKDISKLVLLLSSSVNSLRKAA |
|
Database cross reference |
RefSeq Protein accession:NP_001362
|
Liver relevance
|
HLPP validation |
Yes/No |
Yes |
|
Project name |
Chinese Liver;Human Liver Organelles;French Liver; |
Ontology annotation
| GO-C |
GO:0005858;C:axonemal dynein complex;NAS:UniProtKB. GO:0035085;C:cilium axoneme;IEA:UniProtKB-SubCell. GO:0005737;C:cytoplasm;IEA:UniProtKB-KW. GO:0005874;C:microtubule;IEA:UniProtKB-KW. |
|
GO-F |
GO:0005524;F:ATP binding;IEA:UniProtKB-KW. GO:0016887;F:ATPase activity;IEA:InterPro. GO:0003777;F:microtubule motor activity;NAS:UniProtKB. |
|
GO-P |
GO:0001539;P:ciliary or flagellar motility;NAS:UniProtKB. GO:0007018;P:microtubule-based movement;IEA:InterPro. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr18759 |
PHOSPHORYLATION |
1745 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr18759 |
PHOSPHORYLATION |
2510 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr18759 |
PHOSPHORYLATION |
4058 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr18759 |
PHOSPHORYLATION |
424 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr18759 |
PHOSPHORYLATION |
674 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr18759 |
PHOSPHORYLATION |
3880 |
Y |
PhosphoSitePlus |
HTP |
N |
|
|
|
HuLPr18759 |
PHOSPHORYLATION |
4149 |
Y |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr18759 |
PHOSPHORYLATION |
4163 |
Y |
PhosphoSitePlus |
LTP |
N |
|
