HuLPr21352

Uniprot ID

EMR2_HUMAN

Uniprot Acc

Q9UHX3;E9PBR1;E9PEL6;E9PFQ5;E9PG91;Q8NG96;Q9Y4B1;

Protein name

EGF-like module-containing mucin-like hormone receptor-like 2

Comment

FUNCTION:Receptor probably involved in cell attachment.||SUBUNIT:Forms a heterodimer, consisting of a large extracellular region non-covalently linked to a seven-transmembrane moiety. Interacts with chondroitin sulfate.||SUBCELLULAR LOCATION:Cell membrane; Multi-pass membrane protein.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=5; Comment=A number of isoforms are probably produced. A soluble form due to a frameshift which introduced a stop codon immediately before the first TM domain is also detected; Name=1; IsoId=Q9UHX3-1; Sequence=Displayed; Name=2; IsoId=Q9UHX3-2; Sequence=VSP 041367; Name=3; IsoId=Q9UHX3-3; Sequence=VSP 041366; Name=4; IsoId=Q9UHX3-4; Sequence=VSP 041365; Name=5; IsoId=Q9UHX3-5; Sequence=VSP 041364;||TISSUE SPECIFICITY:Expression is restricted to myeloid cells. Highest expression was found in peripheral blood leukocytes, followed by spleen and lymph nodes, with intermediate to low levels in thymus, bone marrow, fetal liver, pla

Subcellular localization

Cell membrane;Multi-pass membrane protein.

Gene name

egf-like module containing, mucin-like, hormone receptor-like 2

Protein sequence

MGGRVFLVFLAFCVWLTLPGAETQDSRGCARWCPQDSSCV NATACRCNPGFSSFSEIITTPMETCDDINECATLSKVSC GKFSDCWNTEGSYDCVCSPGYEPVSGAKTFKNESENTCQ DVDECQQNPRLCKSYGTCVNTLGSYTCQCLPGFKLKPED PKLCTDVNECTSGQNPCHSSTHCLNNVGSYQCRCRPGWQ PIPGSPNGPNNTVCEDVDECSSGQHQCDSSTVCFNTVGS YSCRCRPGWKPRHGIPNNQKDTVCEDMTFSTWTPPPGVH SQTLSRFFDKVQDLGRDYKPGLANNTIQSILQALDELLE APGDLETLPRLQQHCVASHLLDGLEDVLRGLSKNLSNGL LNFSYPAGTELSLEVQKQVDRSVTLRQNQAVMQLDWNQA QKSGDPGPSVVGLVSIPGMGKLLAEAPLVLEPEKQMLLH ETHQGLLQDGSPILLSDVISAFLSNNDTQNLSSPVTFTF SHRSVIPRQKVLCVFWEHGQNGCGHWATTGCSTIGTRDT STICRCTHLSSFAVLMAHYDVQEEDPVLTVITYMGLSVS LLCLLLAALTFLLCKAIQNTSTSLHLQLSLCLFLAHLLF LVAIDQTGHKVLCSIIAGTLHYLYLATLTWMLLEALYLF LTARNLTVVNYSSINRFMKKLMFPVGYGVPAVTVAISAA SRPHLYGTPSRCWLQPEKGFIWGFLGPVCAIFSVNLVLF LVTLWILKNRLSSLNSEVSTLRNTRMLAFKATAQLFILG CTWCLGILQVGPAARVMAYLFTIINSLQGVFIFLVYCLL SQQVREQYGKWSKGIRKLKTESEMHTLSSSAKADTSKPSTVN

Database cross reference

RefSeq Protein accession:NP_038475
RefSeq Protein gi:23397681

HLPP validation

Yes/No

Yes

Project name

French Liver;Chinese Liver;

GO:0016021;C:integral to membrane;TAS:GDB. GO:0005886;C:plasma membrane;EXP:Reactome.

GO-F

GO:0005509;F:calcium ion binding;IEA:InterPro. GO:0004930;F:G-protein coupled receptor activity;TAS:GDB.

GO-P

GO:0007155;P:cell adhesion;IEA:UniProtKB-KW. GO:0007218;P:neuropeptide signaling pathway;IEA:InterPro.