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Protein basic information

LiverAtlas Protein ID

HuLPr21381

Uniprot ID

ENPL_HUMAN

Uniprot Acc

P14625;Q96A97;

Protein name

Endoplasmin

Comment

FUNCTION:Molecular chaperone that functions in the processing and transport of secreted proteins. Functions in endoplasmic reticulum associated degradation (ERAD). Has ATPase activity.||SUBUNIT:Homodimer; disulfide-linked. Component of an EIF2 complex at least composed of CELF1/CUGBP1, CALR, CALR3, EIF2S1, EIF2S2, HSP90B1 and HSPA5 (By similarity). Part a large chaperone multiprotein complex comprising DNAJB11, HSP90B1, HSPA5, HYOU, PDIA2, PDIA4, PDIA6, PPIB, SDF2L1, UGT1A1 and very small amounts of ERP29, but not, or at very low levels, CALR nor CANX. Interacts with AIMP1; regulates its retention in the endoplasmic reticulum. Interacts with OS9.||INTERACTION:Q9NZJ5:EIF2AK3; NbExp=1; IntAct=EBI-359129, EBI-766076;||SUBCELLULAR LOCATION:Endoplasmic reticulum lumen. Melanosome. Note=Identified by mass spectrometry in melanosome fractions from stage I to stage IV.||SIMILARITY:Belongs to the heat shock protein 90 family.

Subcellular localization

Endoplasmic reticulum lumen.Melanosome.

Gene name

heat shock protein 90kDa beta (Grp94), member 1

Related liver disease name

Hepatocellular carcinoma

Protein sequence

MRALWVLGLCCVLLTFGSVRADDEVDVDGTVEEDLGKSRE GSRTDDEVVQREEEAIQLDGLNASQIRELREKSEKFAFQ AEVNRMMKLIINSLYKNKEIFLRELISNASDALDKIRLI SLTDENALSGNEELTVKIKCDKEKNLLHVTDTGVGMTRE ELVKNLGTIAKSGTSEFLNKMTEAQEDGQSTSELIGQFG VGFYSAFLVADKVIVTSKHNNDTQHIWESDSNEFSVIAD PRGNTLGRGTTITLVLKEEASDYLELDTIKNLVKKYSQF INFPIYVWSSKTETVEEPMEEEEAAKEEKEESDDEAAVE EEEEEKKPKTKKVEKTVWDWELMNDIKPIWQRPSKEVEE DEYKAFYKSFSKESDDPMAYIHFTAEGEVTFKSILFVPT SAPRGLFDEYGSKKSDYIKLYVRRVFITDDFHDMMPKYL NFVKGVVDSDDLPLNVSRETLQQHKLLKVIRKKLVRKTL DMIKKIADDKYNDTFWKEFGTNIKLGVIEDHSNRTRLAK LLRFQSSHHPTDITSLDQYVERMKEKQDKIYFMAGSSRK EAESSPFVERLLKKGYEVIYLTEPVDEYCIQALPEFDGK RFQNVAKEGVKFDESEKTKESREAVEKEFEPLLNWMKDK ALKDKIEKAVVSQRLTESPCALVASQYGWSGNMERIMKA QAYQTGKDISTNYYASQKKTFEINPRHPLIRDMLRRIKE DEDDKTVLDLAVVLFETATLRSGYLLPDTKAYGDRIERM LRLSLNIDPDAKVEEEPEEEPEETAEDTTEDTEQDEDEE MDVGTDEEEETAKESTAEKDEL

Database cross reference

RefSeq Protein accession:NP_003290
RefSeq Protein gi:4507677

Liver relevance

HCC significant Proteins

Yes/No

Yes

Quality score

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Fetal Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005829;C:cytosol;IDA:UniProtKB. GO:0005788;C:endoplasmic reticulum lumen;IDA:UniProtKB. GO:0005789;C:endoplasmic reticulum membrane;IDA:UniProtKB. GO:0042470;C:melanosome;IEA:UniProtKB-SubCell. GO:0005792;C:microsome;IDA:UniProtKB. GO:0030496;C:mi

GO-F

GO:0005524;F:ATP binding;IEA:UniProtKB-KW. GO:0005509;F:calcium ion binding;TAS:UniProtKB. GO:0050750;F:low-density lipoprotein particle receptor binding;IDA:MGI. GO:0019903;F:protein phosphatase binding;IDA:MGI. GO:0003723;F:RNA binding;IDA:UniProtKB.

GO-P

GO:0031247;P:actin rod assembly;IDA:MGI. GO:0006916;P:anti-apoptosis;IMP:UniProtKB. GO:0071318;P:cellular response to ATP;IDA:MGI. GO:0030433;P:ER-associated protein catabolic process;IMP:UniProtKB. GO:000 Error!!! Error!!!Go back to the login page