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Protein basic information

LiverAtlas Protein ID

HuLPr21388

Uniprot ID

ENPP7_HUMAN

Uniprot Acc

Q6UWV6;Q6ZTS5;Q8IUS8;

Protein name

Ectonucleotide pyrophosphatase/phosphodiesterase family member 7

Comment

FUNCTION:Converts sphingomyelin to ceramide. Also has phospholipase C activity toward palmitoyl lyso-phosphocholine. Does not appear to have nucleotide pyrophosphatase activity.||CATALYTIC ACTIVITY:Sphingomyelin + H(2)O = N-acylsphingosine + choline phosphate.||ENZYME REGULATION:Inhibited in a dose dependent manner by ATP, imidazole, orthovanadate and zinc ion. Not inhibited by ADP, AMP and EDTA.||SUBCELLULAR LOCATION:Membrane; Single-pass type I membrane protein (Potential). Note=Localized at the surface of the microvillar membrane in small intestine enterocytes, and in endosome-like structures situated beneath the microvillar membrane, and in Golgi complex.||TISSUE SPECIFICITY:Detected in the colon (at protein level). Expressed in the duodenum, jejunum and liver and at low levels in the ileum. Expression was very low in the esophagus, stomach and colon.||PTM:N-glycosylated; required for activity and transport to the plasma membrane.||MISCELLANEOUS:Decreased levels of alkaline sphingo

Subcellular localization

Membrane;Single-pass type I membrane protein(Potential).

Gene name

ectonucleotide pyrophosphatase/phosphodiesterase 7

Protein sequence

MRGLAVLLTVALATLLAPGAGAPVQSQGSQNKLLLVSFDG FRWNYDQDVDTPNLDAMARDGVKARYMTPAFVTMTSPCH FTLVTGKYIENHGVVHNMYYNTTSKVKLPYHATLGIQRW WDNGSVPIWITAQRQGLRAGSFFYPGGNVTYQGVAVTRS RKEGIAHNYKNETEWRANIDTVMAWFTEEDLDLVTLYFG EPDSTGHRYGPESPERREMVRQVDRTVGYLRESIARNHL TDRLNLIITSDHGMTTVDKRAGDLVEFHKFPNFTFRDIE FELLDYGPNGMLLPKEGRLEKVYDALKDAHPKLHVYKKE AFPEAFHYANNPRVTPLLMYSDLGYVIHGRINVQFNNGE HGFDNKDMDMKTIFRAVGPSFRAGLEVEPFESVHVYELM CRLLGIVPEANDGHLATLLPMLHTESALPPDGRPTLLPK GRSALPPSSRPLLVMGLLGTVILLSEVA

Database cross reference

RefSeq Protein accession:NP_848638
RefSeq Protein gi:45545421

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005794;C:Golgi apparatus;IDA:UniProtKB. GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0005902;C:microvillus;IDA:UniProtKB.

GO-F

GO:0004767;F:sphingomyelin phosphodiesterase activity;IDA:UniProtKB.

GO-P

GO:0008285;P:negative regulation of cell proliferation;IDA:UniProtKB. GO:0008156;P:negative regulation of DNA replication;IDA:UniProtKB. GO:0006684;P:sphingomyelin metabolic process;IDA:UniProtKB.

Pathway

Pathway name

Sphingolipid_Metabolism