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Protein basic information

LiverAtlas Protein ID

HuLPr21520

Uniprot ID

EST2_HUMAN

Uniprot Acc

O00748;Q16859;Q5MAB8;Q7Z366;Q8IUP4;Q8TCP8;

Protein name

Cocaine esterase

Comment

FUNCTION:Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methyumbelliferyl acetate, heroin and 6-monoacetylmorphine.||CATALYTIC ACTIVITY:Cocaine + H(2)O = ecgonine methyl ester + benzoate.||CATALYTIC ACTIVITY:A carboxylic ester + H(2)O = an alcohol + a carboxylate.||SUBUNIT:Monomer.||SUBCELLULAR LOCATION:Endoplasmic reticulum lumen (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=O00748-1; Sequence=Displayed; Name=2; IsoId=O00748-2; Sequence=VSP 010161;||TISSUE SPECIFICITY:Preferentially expressed in intestine with moderate expression in liver. Within the intestine, highest expression is found in small intestine with lower expression in colon and rectum.||PTM:Glycosylated.||SIMILARITY:Belongs to the type-B carboxylesterase/lipase family.||SEQUENCE CAUTION:Sequence=AAH32095.1; Type=Erroneous initiation; Note=Translation N-ter

Subcellular localization

Endoplasmic reticulum lumen(By similarity).

Gene name

carboxylesterase 2

Protein sequence

MRLHRLRARLSAVACGLLLLLVRGQGQDSASPIRTTHTGQ VLGSLVHVKGANAGVQTFLGIPFAKPPLGPLRFAPPEPP ESWSGVRDGTTHPAMCLQDLTAVESEFLSQFNMTFPSDS MSEDCLYLSIYTPAHSHEGSNLPVMVWIHGGALVFGMAS LYDGSMLAALENVVVVIIQYRLGVLGFFSTGDKHATGNW GYLDQVAALRWVQQNIAHFGGNPDRVTIFGESAGGTSVS SLVVSPISQGLFHGAIMESGVALLPGLIASSADVISTVV ANLSACDQVDSEALVGCLRGKSKEEILAINKPFKMIPGV VDGVFLPRHPQELLASADFQPVPSIVGVNNNEFGWLIPK VMRIYDTQKEMDREASQAALQKMLTLLMLPPTFGDLLRE EYIGDNGDPQTLQAQFQEMMADSMFVIPALQVAHFQCSR APVYFYEFQHQPSWLKNIRPPHMKADHGDELPFVFRSFF GGNYIKFTEEEEQLSRKMMKYWANFARNGNPNGEGLPHW PLFDQEEQYLQLNLQPAVGRALKAHRLQFWKKALPQKIQELEEPEERHTEL

Database cross reference

RefSeq Protein accession:NP_003860
RefSeq Protein gi:37622885

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005788;C:endoplasmic reticulum lumen;IEA:UniProtKB-SubCell.

GO-F

GO:0080030;F:methyl indole-3-acetate esterase activity;IEA:EC. GO:0080032;F:methyl jasmonate esterase activity;IEA:EC. GO:0080031;F:methyl salicylate esterase activity;IEA:EC.

GO-P

GO:0009056;P:catabolic process;TAS:ProtInc. GO:0050804;P:regulation of synaptic transmission;ISS:RefGenome.

Pathway

Pathway name

E2F_transcription_factor_network