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Gene, Transcriptome, Protein, Pathway or Disease. 

Protein basic information

LiverAtlas Protein ID

HuLPr21521

Uniprot ID

EST3_HUMAN

Uniprot Acc

Q6UWW8;B2Z3W9;Q7Z6J1;

Protein name

Carboxylesterase 3

Comment

FUNCTION:Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)- 1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics.||CATALYTIC ACTIVITY:A carboxylic ester + H(2)O = an alcohol + a carboxylate.||BIOPHYSICOCHEMICAL PROPERTIES:Kinetic parameters: KM=137 uM for 7-ethyl-10-[4-(1-piperidino)-1-piperidino]- carbonyloxycamptothecin; KM=460 uM for 7-ethyl-10-[4-(1-piperidino)-1-amino]- carbonyloxycamptothecin;||SUBCELLULAR LOCATION:Endoplasmic reticulum lumen (By similarity).||TISSUE SPECIFICITY:Expressed in liver, colon and small intestine.||PTM:N-glycosylated.||SIMILARITY:Belongs to the type-B carboxylesterase/lipase family.||WEB RESOURCE:Name=NIEHS-SNPs; URL="http://egp.gs.washington.edu/data/ces3/";

Subcellular localization

Endoplasmic reticulum lumen(By similarity).

Gene name

carboxylesterase 3

Protein sequence

MERAVRVESGVLVGVVCLLLACPATATGPEVAQPEVDTTL GRVRGRQVGVKGTDRLVNVFLGIPFAQPPLGPDRFSAPH PAQPWEGVRDASTAPPMCLQDVESMNSSRFVLNGKQQIF SVSEDCLVLNVYSPAEVPAGSGRPVMVWVHGGALITGAA TSYDGSALAAYGDVVVVTVQYRLGVLGFFSTGDEHAPGN QGFLDVVAALRWVQENIAPFGGDLNCVTVFGGSAGGSII SGLVLSPVAAGLFHRAITQSGVITTPGIIDSHPWPLAQK IANTLACSSSSPAEMVQCLQQKEGEELVLSKKLKNTIYP LTVDGTVFPKSPKELLKEKPFHSVPFLMGVNNHEFSWLI PRGWGLLDTMEQMSREDMLAISTPVLTSLDVPPEMMPTV IDEYLGSNSDAQAKCQAFQEFMGDVFINVPTVSFSRYLR DSGSPVFFYEFQHRPSSFAKIKPAWVKADHGAEGAFVFG GPFLMDESSRLAFPEATEEEKQLSLTMMAQWTHFARTGD PNSKALPPWPQFNQAEQYLEINPVPRAGQKFREAWMQFW SETLPSKIQQWHQKQKNRKAQEDL

Database cross reference

RefSeq Protein accession:NP_001172105
RefSeq Protein gi:297747271

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005788;C:endoplasmic reticulum lumen;IEA:UniProtKB-SubCell.

GO-F

GO:0004091;F:carboxylesterase activity;IBA:RefGenome. GO:0080030;F:methyl indole-3-acetate esterase activity;IEA:EC. GO:0080032;F:methyl jasmonate esterase activity;IEA:EC. GO:0080031;F:methyl salicylate esterase activity;IEA:EC.

GO-P

GO:0050804;P:regulation of synaptic transmission;IBA:RefGenome.

Pathway

Pathway name

E2F_transcription_factor_network