Choose one of the five choices you want to search:

Gene, Transcriptome, Protein, Pathway or Disease. 

Protein basic information

LiverAtlas Protein ID

HuLPr21522

Uniprot ID

EST4A_HUMAN

Uniprot Acc

Q5XG92;A8KAJ6;B7Z349;B7Z3L2;B7Z6R3;Q6UX55;Q8N9F4;

Protein name

Carboxylesterase 4A

Comment

FUNCTION:Probable carboxylesterase (By similarity).||SUBCELLULAR LOCATION:Secreted (Potential).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=7; Name=1; IsoId=Q5XG92-1; Sequence=Displayed; Note=Gene prediction based on similarity to mouse ortholog; Name=2; IsoId=Q5XG92-2; Sequence=VSP 032483, VSP 032485; Note=No experimental confirmation available. Inactive; Name=3; IsoId=Q5XG92-4; Sequence=VSP 032480; Note=May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay; Name=4; IsoId=Q5XG92-5; Sequence=VSP 040066, VSP 040067; Note=No experimental confirmation available; Name=5; IsoId=Q5XG92-6; Sequence=VSP 040063; Note=No experimental confirmation available; Name=6; IsoId=Q5XG92-7; Sequence=VSP 040063, VSP 040065, VSP 040066, VSP 040067; Note=No experimental confirmation available; Name=7; IsoId=Q5XG92-8; Sequence=VSP 040064, VSP 032483, VSP 040066,

Subcellular localization

Secreted(Potential).

Gene name

carboxylesterase 4A

Protein sequence

MRWILCWSLTLCLMAQTALGALHTKRPQVVTKYGTLQGKQ MHVGKTPIQVFLGVPFSRPPLGILRFAPPEPPEPWKGIR DATTYPPGCLQESWGQLASMYVSTRERYKWLRFSEDCLY LNVYAPARAPGDPQLPVMVWFPGGAFIVGAASSYEGSDL AAREKVVLVFLQHRLGIFGFLSTDDSHARGNWGLLDQMA ALRWVQENIAAFGGDPGNVTLFGQSAGAMSISGLMMSPL ASGLFHRAISQSGTALFRLFITSNPLKVAKKVAHLAGCN HNSTQILVNCLRALSGTKVMRVSNKMRFLQLNFQRDPEE IIWSMSPVVDGVVIPDDPLVLLTQGKVSSVPYLLGVNNL EFNWLLPYIMKFPLNRQAMRKETITKMLWSTRTLLNITK EQVPLVVEEYLDNVNEHDWKMLRNRMMDIVQDATFVYAT LQTAHYHRDAGLPVYLYEFEHHARGIIVKPRTDGADHGD EMYFLFGGPFATGLSMGKEKALSLQMMKYWANFARTGNP NDGNLPCWPRYNKDEKYLQLDFTTRVGMKLKEKKMAFWM SLYQSQRPEKQRQF

Database cross reference

RefSeq Protein accession:NP_001177130
RefSeq Protein gi:298231188

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

Ontology annotation

GO-C

GO:0005576;C:extracellular region;IEA:UniProtKB-SubCell.

GO-F

GO:0004091;F:carboxylesterase activity;ISS:RefGenome.

GO-P

GO:0050804;P:regulation of synaptic transmission;ISS:RefGenome.

Post-translational modification

LiverAtlas Protein ID

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr21522

PHOSPHORYLATION

33

Y

PhosphoSitePlus

1023876

LTP

N

Pathway

Pathway name

E2F_transcription_factor_network