HuLPr21523

Uniprot ID

EST5A_HUMAN

Uniprot Acc

Q6NT32;B7ZLB6;Q8NBC8;Q96DN9;

Protein name

Carboxylesterase 5A

Comment

FUNCTION:Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (By similarity).||CATALYTIC ACTIVITY:A carboxylic ester + H(2)O = an alcohol + a carboxylate.||SUBCELLULAR LOCATION:Secreted (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q6NT32-1; Sequence=Displayed; Name=2; IsoId=Q6NT32-2; Sequence=VSP 029006; Name=3; IsoId=Q6NT32-3; Sequence=VSP 029005; Note=No experimental confirmation available;||PTM:N-glycosylated (By similarity).||SIMILARITY:Belongs to the type-B carboxylesterase/lipase family.||CAUTION:Was termed (Ref.1) CES5.

Subcellular localization

Secreted(By similarity).

Gene name

carboxylesterase 5A

Protein sequence

MSGNWVHPGQILIWAIWVLAAPTKGPSAEGPQRNTRLGWI QGKQVTVLGSPVPVNVFLGVPFAAPPLGSLRFTNPQPAS PWDNLREATSYPNLCLQNSEWLLLDQHMLKVHYPKFGVS EDCLYLNIYAPAHADTGSKLPVLVWFPGGAFKTGSASIF DGSALAAYEDVLVVVVQYRLGIFGFFTTWDQHAPGNWAF KDQVAALSWVQKNIEFFGGDPSSVTIFGESAGAISVSSL ILSPMAKGLFHKAIMESGVAIIPYLEAHDYEKSEDLQVV AHFCGNNASDSEALLRCLRTKPSKELLTLSQKTKSFTRV VDGAFFPNEPLDLLSQKAFKAIPSIIGVNNHECGFLLPM KEAPEILSGSNKSLALHLIQNILHIPPQYLHLVANEYFH DKHSLTEIRDSLLDLLGDVFFVVPALITARYHRDAGAPV YFYEFRHRPQCFEDTKPAFVKADHADEVRFVFGGAFLKG DIVMFEGATEEEKLLSRKMMKYWATFARTGNPNGNDLSL WPAYNLTEQYLQLDLNMSLGQRLKEPRVDFWTSTIPLIL SASDMLHSPLSSLTFLSLLQPFFFFCAP

Database cross reference

RefSeq Protein accession:NP_001137157
RefSeq Protein gi:219521907

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

GO:0005576;C:extracellular region;IEA:UniProtKB-SubCell.

GO-F

GO:0080030;F:methyl indole-3-acetate esterase activity;IEA:EC. GO:0080032;F:methyl jasmonate esterase activity;IEA:EC. GO:0080031;F:methyl salicylate esterase activity;IEA:EC.

GO-P

GO:0050804;P:regulation of synaptic transmission;ISS:RefGenome.

E2F_transcription_factor_network