HuLPr21573

Uniprot ID

EXOG_HUMAN

Uniprot Acc

Q9Y2C4;A8K242;B4DVG2;Q3SXM9;Q9Y2C8;

Protein name

Nuclease EXOG, mitochondrial

Comment

FUNCTION:Endo/exonuclease with nicking activity towards supercoiled DNA, a preference for single stranded DNA and 5'-3' exonuclease activity.||COFACTOR:Divalent metal cations.||SUBUNIT:Homodimer.||SUBCELLULAR LOCATION:Mitochondrion inner membrane.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=4; Name=1; Synonyms=ENGL-a; IsoId=Q9Y2C4-1; Sequence=Displayed; Name=2; Synonyms=ENDOGL2, ENGL-b; IsoId=Q9Y2C4-2; Sequence=VSP 034506, VSP 034507, VSP 034508; Note=No experimental confirmation available. Probably inactive since it lacks the active site; Name=3; IsoId=Q9Y2C4-3; Sequence=VSP 034506; Note=Probably inactive since it lacks the active site; Name=4; IsoId=Q9Y2C4-4; Sequence=VSP 041214;||TISSUE SPECIFICITY:Ubiquitous.||MISCELLANEOUS:The active site contains 1 hydrated divalent metal cation that has only 1 direct interaction with the protein; all other interactions are via water molecules (By similarity).||SIMILARITY:Belongs to the DNA/RNA non-specific endo

Subcellular localization

Mitochondrion inner membrane.

Gene name

endo/exonuclease (5'-3'), endonuclease G-like

Protein sequence

MAIKSIASRLRGSRRFLSGFVAGAVVGAAGAGLAALQFFR SQGAEGALTGKQPDGSAEKAVLEQFGFPLTGTEARCYTN HALSYDQAKRVPRWVLEHISKSKIMGDADRKHCKFKPDP NIPPTFSAFNEDYVGSGWSRGHMAPAGNNKFSSKAMAET FYLSNIVPQDFDNNSGYWNRIEMYCRELTERFEDVWVVS GPLTLPQTRGDGKKIVSYQVIGEDNVAVPSHLYKVILAR RSSVSTEPLALGAFVVPNEAIGFQPQLTEFQVSLQDLEK LSGLVFFPHLDRTSDIRNICSVDTCKLLDFQEFTLYLST RKIEGARSVLRLEKIMENLKNAEIEPDDYFMSRYEKKLE ELKAKEQSGTQIRKPS

Database cross reference

RefSeq Protein accession:NP_001138936
RefSeq Protein gi:224451075

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

GO:0005743;C:mitochondrial inner membrane;IEA:UniProtKB-SubCell.

GO-F

GO:0004519;F:endonuclease activity;NAS:UniProtKB. GO:0046872;F:metal ion binding;IEA:UniProtKB-KW. GO:0003676;F:nucleic acid binding;IEA:InterPro.