HuLPr22058

Uniprot ID

F2WG54_HUMAN

Uniprot Acc

F2WG54;

Protein name

Cytochrome c oxidase subunit 1

Comment

FUNCTION:Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B (By similarity).||CATALYTIC ACTIVITY:4 ferrocytochrome c + O(2) + 4 H(+) = 4 ferricytochrome c + 2 H(2)O.||PATHWAY:Energy metabolism; oxidative phosphorylation.||SUBCELLULAR LOCATION:Mitochondrion inner membrane; Multi-pass membrane protein (By similarity).||SIMILARITY:Belongs to the heme-copper respiratory oxidase family.

Subcellular localization

Mitochondrion inner membrane;Multi-pass membrane protein(By similarity).

Gene name

cytochrome c oxidase subunit I

Protein sequence

MFADRWLFSTNHKDIGTLYLLFGAWAGVLGTALSLLIRAX LGQPGNLLGXDHIYNVIVTAHAFVMIFFMVMPIMIGGFG NWLVPLMIGAPDMAFPRMNNMSFWLLPPSLLLLLASAMV EAGAGTGWTVYPPLAGNYSHPGASVDLTIFSLHLAGXSS ILGAINFITTIINMKPPAMTQYQTPLFVWSVLITAVLLL LSLPVLAAGITMLLTDRNLNTTFFDPAGGGDPILYQHLF WFFGHPEVYILILPGFGMISHIVTYYSGKKEPFGYMGMV WAMMSIGFLGFIVWAHHMFTVGMDVDTRAYFTSATMIIA IPTGVKVFSWLATLHGSNMKWSAAVLWALGFIFLFTVGG LTGIVLANSSLDIVLHDTYYVVAHFHYVLSMGAVFAIMG GFIHWFPLFSGYTLDQTYAKIHFTIMFIGVNLTFFPQHF LGLSGMPRRYSDYPDAYTTWNILSSVGSFISLTAVMLMI FMIWEAFASKRKVLMVEEPSMNLEWLYGCPPPYHTFEEPVYMKS

Database cross reference

RefSeq Protein accession:YP_003024028
RefSeq Protein gi:251831109

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

GO:0016021;C:integral to membrane;IEA:InterPro. GO:0005739;C:mitochondrion;IEA:UniProtKB-KW.

GO-F

GO:0009055;F:electron carrier activity;IEA:InterPro. GO:0020037;F:heme binding;IEA:InterPro.

GO-P

GO:0009060;P:aerobic respiration;IEA:InterPro.