Protein basic information
| LiverAtlas Protein ID |
HuLPr23187 |
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Uniprot ID |
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Uniprot Acc |
P00740;A8K9N4;Q5JYJ8; |
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Protein name |
Coagulation factor IX |
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Comment |
FUNCTION:Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.||CATALYTIC ACTIVITY:Selective cleavage of Arg-|-Ile bond in factor X to form factor Xa.||SUBUNIT:Heterodimer of a light chain and a heavy chain; disulfide-linked.||SUBCELLULAR LOCATION:Secreted.||TISSUE SPECIFICITY:Synthesized primarily in the liver and secreted in plasma.||DOMAIN:Calcium binds to the gamma-carboxyglutamic acid (Gla) residues and, with stronger affinity, to another site, beyond the Gla domain.||PTM:Activated by factor XIa, which excises the activation peptide.||PTM:The iron and 2-oxoglutarate dependent 3-hydroxylation of aspartate and asparagine is (R) stereospecific within EGF domains.||DISEASE:Defects in F9 are the cause of recessive X-linked hemophilia B (HEMB) [MIM:306900]; also known as Christmas disease.||DISEASE:Note=Mutations in positi |
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Subcellular localization |
Secreted. |
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Gene name |
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Protein sequence
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MQRVNMIMAESPGLITICLLGYLLSAECTVFLDHENANKI LNRPKRYNSGKLEEFVQGNLERECMEEKCSFEEAREVFE NTERTTEFWKQYVDGDQCESNPCLNGGSCKDDINSYECW CPFGFEGKNCELDVTCNIKNGRCEQFCKNSADNKVVCSC TEGYRLAENQKSCEPAVPFPCGRVSVSQTSKLTRAETVF PDVDYVNSTEAETILDNITQSTQSFNDFTRVVGGEDAKP GQFPWQVVLNGKVDAFCGGSIVNEKWIVTAAHCVETGVK ITVVAGEHNIEETEHTEQKRNVIRIIPHHNYNAAINKYN HDIALLELDEPLVLNSYVTPICIADKEYTNIFLKFGSGY VSGWGRVFHKGRSALVLQYLRVPLVDRATCLRSTKFTIY NNMFCAGFHEGGRDSCQGDSGGPHVTEVEGTSFLTGIIS WGEECAMKGKYGIYTKVSRYVNWIKEKTKLT |
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Database cross reference |
RefSeq Protein accession:NP_000124
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Liver relevance
| Liver sepcificity |
Yes/No |
Yes |
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Evidence |
UniProtein |
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Quality score |
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| Liver sepcificity |
Yes/No |
Yes |
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Evidence |
Translational level from literatures |
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Quality score |
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HLPP validation |
Yes/No |
Yes |
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Project name |
Chinese Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005788;C:endoplasmic reticulum lumen;TAS:Reactome. GO:0005576;C:extracellular region;NAS:UniProtKB. GO:0005796;C:Golgi lumen;TAS:Reactome. GO:0005886;C:plasma membrane;EXP:Reactome. |
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GO-F |
GO:0005509;F:calcium ion binding;IEA:InterPro. GO:0004252;F:serine-type endopeptidase activity;TAS:ProtInc. |
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GO-P |
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