Choose one of the five choices you want to search:

Gene, Transcriptome, Protein, Pathway or Disease. 

Protein basic information

LiverAtlas Protein ID

HuLPr23213

Uniprot ID

FADS2_HUMAN

Uniprot Acc

O95864;A8K2M6;Q6MZQ7;Q96H07;Q96SV8;Q9H3G3;Q9Y3X4;

Protein name

Fatty acid desaturase 2

Comment

FUNCTION:Component of a lipid metabolic pathway that catalyzes biosynthesis of highly unsaturated fatty acids (HUFA) from precursor essential polyunsaturated fatty acids (PUFA) linoleic acid (LA) (18:2n-6) and alpha-linolenic acid (ALA) (18:3n-3). Catalyzes the first and rate limiting step in this pathway which is the desaturation of LA (18:2n-6) and ALA (18:3n-3) into gamma- linoleic acid (GLA) (18:3n-6) and stearidonic acid (18:4n-3) respectively and other desaturation steps. Highly unsaturated fatty acids (HUFA) play pivotal roles in many biological functions. It catalizes as well the introduction of a cis double bond in palmitate to produce the mono-unsaturated fatty acid sapienate, the most abundant fatty acid in sebum.||PATHWAY:Lipid metabolism; polyunsaturated fatty acid biosynthesis.||SUBCELLULAR LOCATION:Endoplasmic reticulum membrane; Multi-pass membrane protein (Potential).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=O95864-1; Sequence

Subcellular localization

Endoplasmic reticulum membrane;Multi-pass membrane protein(Potential).

Gene name

fatty acid desaturase 2

Protein sequence

MGKGGNQGEGAAEREVSVPTFSWEEIQKHNLRTDRWLVID RKVYNITKWSIQHPGGQRVIGHYAGEDATDAFRAFHPDL EFVGKFLKPLLIGELAPEEPSQDHGKNSKITEDFRALRK TAEDMNLFKTNHVFFLLLLAHIIALESIAWFTVFYFGNG WIPTLITAFVLATSQAQAGWLQHDYGHLSVYRKPKWNHL VHKFVIGHLKGASANWWNHRHFQHHAKPNIFHKDPDVNM LHVFVLGEWQPIEYGKKKLKYLPYNHQHEYFFLIGPPLL IPMYFQYQIIMTMIVHKNWVDLAWAVSYYIRFFITYIPF YGILGALLFLNFIRFLESHWFVWVTQMNHIVMEIDQEAY RDWFSSQLTATCNVEQSFFNDWFSGHLNFQIEHHLFPTM PRHNLHKIAPLVKSLCAKHGIEYQEKPLLRALLDIIRSL KKSGKLWLDAYLHK

Database cross reference

RefSeq Protein accession:NP_004256
RefSeq Protein gi:4758334

Liver relevance

HLPP validation

Yes/No

Yes

Project name

French Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005789;C:endoplasmic reticulum membrane;IEA:UniProtKB-SubCell. GO:0005887;C:integral to plasma membrane;TAS:ProtInc. GO:0005624;C:membrane fraction;TAS:ProtInc.

GO-F

GO:0020037;F:heme binding;IEA:InterPro.

GO-P

GO:0022900;P:electron transport chain;IEA:UniProtKB-KW. GO:0006810;P:transport;IEA:UniProtKB-KW. GO:0006636;P:unsaturated fatty acid biosynthetic process;TAS:ProtInc.

Pathway

Pathway name

Alpha_Linolenic_Acid_and_Linoleic_Acid_Metabolism