Protein basic information
| LiverAtlas Protein ID |
HuLPr23221 |
|
Uniprot ID |
|
|
Uniprot Acc |
O60667;A8K7J2; |
|
Protein name |
Fas apoptotic inhibitory molecule 3 |
|
Comment |
FUNCTION:May play a role in the immune system processes. Protects cells from FAS-, TNF alpha- and FADD-induced apoptosis without increasing expression of the inhibitors of apoptosis BCL2 and BCLXL. Seems to activate an inhibitory pathway that prevents CASP8 activation following FAS stimulation, rather than blocking apoptotic signals downstream. May inhibit FAS-induced apoptosis by preventing CASP8 processing through CFLAR up-regulation.||SUBCELLULAR LOCATION:Membrane; Single-pass membrane protein (Potential).||TISSUE SPECIFICITY:Expressed in lymph nodes, peripheral blood leukocytes, lung, thymus and kidneys. Very weak expression detected in spleen, liver, heart, and salivary gland. Expressed in lymphoid cell lines such as Jurkat cells, CemT4 cells, MolT-4 cells, HB11.19 cells, and Reh cells. No expression detected in nonhematopoietic cell lines, including HepG2 cells, 293 cells and Hela cells.||INDUCTION:By T-cell activation.||DOMAIN:The Ig-like domain is required for the anti-apoptoti |
|
Subcellular localization |
Membrane;Single-pass membrane protein(Potential). |
|
Gene name |
|
|
Protein sequence
|
MDFWLWPLYFLPVSGALRILPEVKVEGELGGSVTIKCPLP EMHVRIYLCREMAGSGTCGTVVSTTNFIKAEYKGRVTLK QYPRKNLFLVEVTQLTESDSGVYACGAGMNTDRGKTQKV TLNVHSEYEPSWEEQPMPETPKWFHLPYLFQMPAYASSS KFVTRVTTPAQRGKVPPVHHSSPTTQITHRPRVSRASSV AGDKPRTFLPSTTASKISALEGLLKPQTPSYNHHTRLHR QRALDYGSQSGREGQGFHILIPTILGLFLLALLGLVVKR AVERRKALSRRARRLAVRMRALESSQRPRGSPRPRSQNN IYSACPRRARGADAAGTGEAPVPGPGAPLPPAPLQVSES PWLHAPSLKTSCEYVSLYHQPAAMMEDSDSDDYINVPA |
|
Database cross reference |
RefSeq Protein accession:NP_001135945
|
Liver relevance
|
HLPP validation |
Yes/No |
Yes |
|
Project name |
Chinese Liver; |
Ontology annotation
| GO-C |
GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. |
|
GO-P |
GO:0006916;P:anti-apoptosis;TAS:ProtInc. GO:0006968;P:cellular defense response;TAS:ProtInc. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr23221 |
PHOSPHORYLATION |
315 |
Y |
PhosphoSitePlus |
LTP |
N |
 
|
Pathway
| Pathway name | |
| Pathway name |
