Protein basic information
| LiverAtlas Protein ID |
HuLPr23252 |
|
Uniprot ID |
|
|
Uniprot Acc |
Q9Y4F1;Q6IQ29; |
|
Protein name |
FERM, RhoGEF and pleckstrin domain-containing protein 1 |
|
Comment |
FUNCTION:May function as Rho-guanine nucleotide exchange factor (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=3; Name=1; IsoId=Q9Y4F1-1; Sequence=Displayed; Name=2; IsoId=Q9Y4F1-2; Sequence=VSP 017976; Note=No experimental confirmation available; Name=3; IsoId=Q9Y4F1-3; Sequence=VSP 040989, VSP 040990;||TISSUE SPECIFICITY:Detected in cAMP-treated chondrocytes, but not in untreated chondrocytes. Detected in fetal brain, heart and spleen, and in adult testis, kidney and lung.||INDUCTION:Up-regulated in response to cAMP in cultured embryonic chondrocytes.||SIMILARITY:Contains 1 DH (DBL-homology) domain.||SIMILARITY:Contains 1 FERM domain.||SIMILARITY:Contains 2 PH domains. |
|
Gene name |
FERM, RhoGEF (ARHGEF) and pleckstrin domain protein 1 (chondrocyte-derived) |
|
Protein sequence
|
MGEIEQRPTPGSRLGAPENSGISTLERGQKPPPTPSGKLV SIKIQMLDDTQEAFEVPQRAPGKVLLDAVCNHLNLVEGD YFGLEFPDHKKITVWLDLLKPIVKQIRRPKHVVVKFVVK FFPPDHTQLQEELTRYLFALQVKQDLAQGRLTCNDTSAA LLISHIVQSEIGDFDEALDREHLAKNKYIPQQDALEDKI VEFHHNHIGQTPAESDFQLLEIARRLEMYGIRLHPAKDR EGTKINLAVANTGILVFQGFTKINAFNWAKVRKLSFKRK RFLIKLRPDANSAYQDTLEFLMASRDFCKSFWKICVEHH AFFRLFEEPKPKPKPVLFSRGSSFRFSGRTQKQVLDYVK EGGHKKVQFERKHSKIHSIRSLASQPTELNSEVLEQSQQ STSLTFGEGAESPGGQSCRRGKEPKVSAGEPGSHPSPAP RRSPAGNKQADGAASAPTEEEEEVVKDRTQQSKPQPPQP STGSLTGSPHLSELSVNSQGGVAPANVTLSPNLSPDTKQ ASPLISPLLNDQACPRTDDEDEGRRKRFPTDKAYFIAKE VSTTERTYLKDLEVITSWFQSTVSKEDAMPEALKSLIFP NFEPLHKFHTNFLKEIEQRLALWEGRSNAQIRDYQRIGD VMLKNIQGMKHLAAHLWKHSEALEALENGIKSSRRLENF CRDFELQKVCYLPLNTFLLRPLHRLMHYKQVLERLCKHH PPSHADFRDCRAALAEITEMVAQLHGTMIKMENFQKLHE LKKDLIGIDNLVVPGREFIRLGSLSKLSGKGLQQRMFFL FNDVLLYTSRGLTASNQFKVHGQLPLYGMTIEESEDEWG VPHCLTLRGQRQSIIVAASSRSEMEKWVEDIQMAIDLAE KSSSPAPEFLASSPPDNKSPDEATAADQESEDDLSASRT SLERQAPHRGNTMVHVCWHRNTSVSMVDFSIAVENQLSG NLLRKFKNSNGWQKLWVVFTNFCLFFYKSHQDNHPLASL PLLGYSLTIPSESENIQKDYVFKL |
|
Database cross reference |
RefSeq Protein accession:NP_001001715
|
Liver relevance
|
HLPP validation |
Yes/No |
Yes |
|
Project name |
Chinese Liver;Human Fetal Liver;Human Liver Organelles; |
Ontology annotation
| GO-C |
GO:0005737;C:cytoplasm;IEA:InterPro. GO:0005856;C:cytoskeleton;TAS:ProtInc. GO:0019898;C:extrinsic to membrane;IEA:InterPro. |
|
GO-F |
GO:0008092;F:cytoskeletal protein binding;IEA:InterPro. GO:0005089;F:Rho guanyl-nucleotide exchange factor activity;TAS:ProtInc. |
|
GO-P |
GO:0035023;P:regulation of Rho protein signal transduction;IEA:InterPro. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr23252 |
PHOSPHORYLATION |
23 |
S |
Phospho-ELM |
HTP |
yes |
 
|
|
|
HuLPr23252 |
PHOSPHORYLATION |
24 |
T |
Phospho-ELM |
HTP |
yes |
|
|
|
HuLPr23252 |
PHOSPHORYLATION |
336 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr23252 |
PHOSPHORYLATION |
340 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr23252 |
PHOSPHORYLATION |
427 |
S |
Phospho-ELM |
HTP |
yes |
|
|
|
HuLPr23252 |
PHOSPHORYLATION |
872 |
S |
Phospho-ELM |
HTP |
N |
|
|
|
HuLPr23252 |
PHOSPHORYLATION |
418 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr23252 |
PHOSPHORYLATION |
871 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr23252 |
PHOSPHORYLATION |
510 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr23252 |
PHOSPHORYLATION |
514 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr23252 |
PHOSPHORYLATION |
525 |
T |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr23252 |
PHOSPHORYLATION |
899 |
S |
PhosphoSitePlus |
LTP |
yes |
|
|
|
HuLPr23252 |
PHOSPHORYLATION |
896 |
S |
PhosphoSitePlus |
HTP |
yes |
|
|
|
HuLPr23252 |
PHOSPHORYLATION |
23 |
S |
PhosphoSitePlus |
LTP |
yes |
|
|
|
HuLPr23252 |
PHOSPHORYLATION |
340 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr23252 |
PHOSPHORYLATION |
872 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr23252 |
PHOSPHORYLATION |
24 |
T |
PhosphoSitePlus |
LTP |
yes |
|
|
|
HuLPr23252 |
PHOSPHORYLATION |
427 |
S |
PhosphoSitePlus |
LTP |
yes |
|
|
|
HuLPr23252 |
PHOSPHORYLATION |
889 |
S |
PhosphoSitePlus |
LTP |
yes |
|
|
|
HuLPr23252 |
PHOSPHORYLATION |
898 |
T |
PhosphoSitePlus |
LTP |
yes |
|
Pathway
| Pathway name |
