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Protein basic information

LiverAtlas Protein ID

HuLPr23254

Uniprot ID

FAS_HUMAN

Uniprot Acc

P49327;Q13479;Q16702;Q4LE83;Q6P4U5;Q6SS02;Q969R1;Q96C68;Q96IT0;

Protein name

Fatty acid synthase

Comment

FUNCTION:Fatty acid synthetase catalyzes the formation of long- chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. This multifunctional protein has 7 catalytic activities and an acyl carrier protein.||CATALYTIC ACTIVITY:Acetyl-CoA + n malonyl-CoA + 2n NADPH = a long-chain fatty acid + (n+1) CoA + n CO(2) + 2n NADP(+).||CATALYTIC ACTIVITY:Acetyl-CoA + [acyl-carrier-protein] = CoA + acetyl-[acyl-carrier-protein].||CATALYTIC ACTIVITY:Malonyl-CoA + [acyl-carrier-protein] = CoA + malonyl-[acyl-carrier-protein].||CATALYTIC ACTIVITY:Acyl-[acyl-carrier-protein] + malonyl-[acyl- carrier-protein] = 3-oxoacyl-[acyl-carrier-protein] + CO(2) + [acyl-carrier-protein].||CATALYTIC ACTIVITY:(3R)-3-hydroxyacyl-[acyl-carrier-protein] + NADP(+) = 3-oxoacyl-[acyl-carrier-protein] + NADPH.||CATALYTIC ACTIVITY:(3R)-3-hydroxypalmitoyl-[acyl-carrier-protein] = hexadec-2-enoyl-[acyl-carrier-protein] + H(2)O.||CATALYTIC ACTIVITY:Acyl-[acyl-carrier-protein] + NADP(+) = trans- 2,3-dehydroacyl-[acyl-carrier-

Subcellular localization

Cytoplasm.Melanosome.

Gene name

fatty acid synthase

Related liver disease name

Hepatocellular carcinoma

Protein sequence

MEEVVIAGMSGKLPESENLQEFWDNLIGGVDMVTDDDRRW KAGLYGLPRRSGKLKDLSRFDASFFGVHPKQAHTMDPQL RLLLEVTYEAIVDGGINPDSLRGTHTGVWVGVSGSETSE ALSRDPETLVGYSMVGCQRAMMANRLSFFFDFRGPSIAL DTACSSSLMALQNAYQAIHSGQCPAAIVGGINVLLKPNT SVQFLRLGMLSPEGTCKAFDTAGNGYCRSEGVVAVLLTK KSLARRVYATILNAGTNTDGFKEQGVTFPSGDIQEQLIR SLYQSAGVAPESFEYIEAHGTGTKVGDPQELNGITRALC ATRQEPLLIGSTKSNMGHPEPASGLAALAKVLLSLEHGL WAPNLHFHSPNPEIPALLDGRLQVVDQPLPVRGGNVGIN SFGFGGSNVHIILRPNTQPPPAPAPHATLPRLLRASGRT PEAVQKLLEQGLRHSQDLAFLSMLNDIAAVPATAMPFRG YAVLGGERGGPEVQQVPAGERPLWFICSGMGTQWRGMGL SLMRLDRFRDSILRSDEAVKPFGLKVSQLLLSTDESTFD DIVHSFVSLTAIQIGLIDLLSCMGLRPDGIVGHSLGEVA CGYADGCLSQEEAVLAAYWRGQCIKEAHLPPGAMAAVGL SWEECKQRCPPGVVPACHNSKDTVTISGPQAPVFEFVEQ LRKEGVFAKEVRTGGMAFHSYFMEAIAPPLLQELKKVIR EPKPRSARWLSTSIPEAQWHSSLARTSSAEYNVNNLVSP VLFQEALWHVPEHAVVLEIAPHALLQAVLKRGLKPSCTI IPLMKKDHRDNLEFFLAGIGRLHLSGIDANPNALFPPVE FPAPRGTPLISPLIKWDHSLAWDVPAAEDFPNGSGSPSA AIYNIDTSSESPDHYLVDHTLDGRVLFPATGYLSIVWKT LARALGLGVEQLPVVFEDVVLHQATILPKTGTVSLEVRL LEASRAFEVSENGNLVVSGKVYQWDDPDPRLFDHPESPT PNPTEPLFLAQAEVYKELRLRGYD

Database cross reference

RefSeq Protein accession:NP_004095
RefSeq Protein gi:41872631

Liver relevance

HCC significant Proteins

Yes/No

Yes

Quality score

HLPP validation

Yes/No

Yes

Project name

French Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005829;C:cytosol;EXP:Reactome. GO:0005794;C:Golgi apparatus;IDA:HPA. GO:0042470;C:melanosome;IEA:UniProtKB-SubCell. GO:0005886;C:plasma membrane;IDA:HPA.

GO-F

GO:0004317;F:3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase activity;IEA:EC. GO:0004316;F:3-oxoacyl-[acyl-carrier-protein] reductase activity;IEA:EC. GO:0004315;F:3-oxoacyl-[acyl-carrier-protein] synthase activity;IEA:EC. GO:0004313;F:[acyl-carri

GO-P

GO:0006112;P:energy reserve metabolic process;TA Error!!! Error!!!Go back to the login page