Choose one of the five choices you want to search:

Gene, Transcriptome, Protein, Pathway or Disease. 

Protein basic information

LiverAtlas Protein ID

HuLPr23326

Uniprot ID

FCAMR_HUMAN

Uniprot Acc

Q8WWV6;Q32M82;Q8WWV5;Q96SA2;

Protein name

High affinity immunoglobulin alpha and immunoglobulin mu Fc receptor

Comment

FUNCTION:Functions as a receptor for the Fc fragment of IgA and IgM. Binds IgA and IgM with high affinity and mediates their endocytosis. May function in the immune response to microbes mediated by IgA and IgM.||SUBCELLULAR LOCATION:Cell membrane; Single-pass type I membrane protein (By similarity).||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=4; Name=1; IsoId=Q8WWV6-1; Sequence=Displayed; Name=2; IsoId=Q8WWV6-2; Sequence=VSP 033228, VSP 033229; Note=No experimental confirmation available; Name=3; IsoId=Q8WWV6-3; Sequence=VSP 033227, VSP 033230, VSP 033232; Note=No experimental confirmation available; Name=4; IsoId=Q8WWV6-4; Sequence=VSP 033231;||TISSUE SPECIFICITY:Expressed by mesangial cells.||INDUCTION:Up-regulated by IFNG/IFN-gamma in mesangial cells.||PTM:N-glycosylated.||SIMILARITY:Contains 1 Ig-like V-type (immunoglobulin-like) domain.||SEQUENCE CAUTION:Sequence=AAI09264.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequen

Subcellular localization

Cell membrane;Single-pass type I membrane protein(By similarity).

Gene name

Fc receptor, IgA, IgM, high affinity

Protein sequence

MPLFLILCLLQGSSFALPQKRPHPRWLWEGSLPSRTHLRA MGTLRPSSPLCWREESSFAAPNSLKGSRLVSGEPGGAVT IQCHYAPSSVNRHQRKYWCRLGPPRWICQTIVSTNQYTH HRYRDRVALTDFPQRGLFVVRLSQLSPDDIGCYLCGIGS ENNMLFLSMNLTISAGPASTLPTATPAAGELTMRSYGTA SPVANRWTPGTTQTLGQGTAWDTVASTPGTSKTTASAEG RRTPGATRPAAPGTGSWAEGSVKAPAPIPESPPSKSRSM SNTTEGVWEGTRSSVTNRARASKDRREMTTTKADRPRED IEGVRIALDAAKKVLGTIGPPALVSETLAWEILPQATPV SKQQSQGSIGETTPAAGMWTLGTPAADVWILGTPAADVW TSMEAASGEGSAAGDLDAATGDRGPQATLSQTPAVGPWG PPGKESSVKRTFPEDESSSRTLAPVSTMLALFMLMALVL LQRKLWRRRTSQEAERVTLIQMTHFLEVNPQADQLPHVE RKMLQDDSLPAGASLTAPERNPGP

Database cross reference

RefSeq Protein accession:NP_001116451
RefSeq Protein gi:172072600

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

Ontology annotation

GO-C

GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0005886;C:plasma membrane;IEA:UniProtKB-SubCell.

GO-F

GO:0004872;F:receptor activity;IEA:UniProtKB-KW.

Post-translational modification

LiverAtlas Protein ID

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr23326

PHOSPHORYLATION

96

Y

PhosphoSitePlus

1024828

LTP

N

Pathway

Pathway name

CD40/CD40L_signaling