HuLPr23337

Uniprot ID

FCG3B_HUMAN

Uniprot Acc

O75015;

Protein name

Low affinity immunoglobulin gamma Fc region receptor III-B

Comment

FUNCTION:Receptor for the Fc region of immunoglobulins gamma. Low affinity receptor. Binds complexed or aggregated IgG and also monomeric IgG. Contrary to III-A, is not capable to mediate antibody-dependent cytotoxicity and phagocytosis. May serve as a trap for immune complexes in the peripheral circulation which does not activate neutrophils.||SUBUNIT:Monomer. Interacts with INPP5D/SHIP1 (By similarity).||SUBCELLULAR LOCATION:Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Secreted after cleavage.||TISSUE SPECIFICITY:Expressed specifically by polymorphonuclear leukocytes (neutrophils). Also expressed by stimulated eosinophils.||PTM:Glycosylated. Glycosylation plays an inhibitory role in the interaction with IgG3.||PTM:The soluble form is produced by a proteolytic cleavage.||POLYMORPHISM:There are three allelic forms of FCGR3B:FCGR3B*01 (NA-1), FCGR3B*02 (HNA-1b, NA-2) (shown here) and SH. FCGR3B*01 and FCGR3B*02 are detectable with antibodies against the biallelic neutrophil-s

Subcellular localization

Cell membrane;Lipid-anchor, GPI-anchor.Secreted.

Gene name

Fc fragment of IgG, low affinity IIIb, receptor (CD16b)

Protein sequence

MWQLLLPTALLLLVSAGMRTEDLPKAVVFLEPQWYSVLEK DSVTLKCQGAYSPEDNSTQWFHNESLISSQASSYFIDAA TVNDSGEYRCQTNLSTLSDPVQLEVHIGWLLLQAPRWVF KEEDPIHLRCHSWKNTALHKVTYLQNGKDRKYFHHNSDF HIPKATLKDSGSYFCRGLVGSKNVSSETVNITITQGLAV STISSFSPPGYQVSFCLVMVLLFAVDTGLYFSVKTNI

Database cross reference

RefSeq Protein accession:NP_000561
RefSeq Protein gi:132814489

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

GO:0031225;C:anchored to membrane;IEA:UniProtKB-KW. GO:0005576;C:extracellular region;IEA:UniProtKB-SubCell. GO:0005886;C:plasma membrane;IEA:UniProtKB-SubCell.

GO-F

GO:0019864;F:IgG binding;IEA:UniProtKB-KW. GO:0004872;F:receptor activity;IEA:UniProtKB-KW.

GO-P

GO:0006955;P:immune response;TAS:ProtInc.