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Protein basic information

LiverAtlas Protein ID

HuLPr23410

Uniprot ID

FGFR1_HUMAN

Uniprot Acc

P11362;A8K6T9;A8K8V5;C1KBH8;P17049;Q02063;Q02065;Q14306;Q14307;Q53H63;Q5BJG2;Q8N685;Q9UD50;Q9UDF0;Q9UDF1;Q9UDF2;

Protein name

Basic fibroblast growth factor receptor 1

Comment

FUNCTION:Receptor for fibroblast growth factors FGF2 and FGF1. Receptor for FGF23 in the presence of KL (By similarity). Promotes mitogenesis in response to fibroblast growth factors. Activates PLCG1.||CATALYTIC ACTIVITY:ATP + a [protein]-L-tyrosine = ADP + a [protein]-L-tyrosine phosphate.||SUBUNIT:Homodimer. Interacts with KLB (By similarity). Interacts with KL and FGF23 (By similarity). Interacts with SHB and GRB10. Interacts with PLCG1 (via SH2 domains).||INTERACTION:P12830:CDH1; NbExp=1; IntAct=EBI-1028277, EBI-727477; P35222:CTNNB1; NbExp=1; IntAct=EBI-1028277, EBI-491549; P05230:FGF1; NbExp=1; IntAct=EBI-1028277, EBI-698068; P10686:Plcg1 (xeno); NbExp=3; IntAct=EBI-1028277, EBI-520788;||SUBCELLULAR LOCATION:Membrane; Single-pass type I membrane protein.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=19; Name=1; Synonyms=Alpha A1, IV; IsoId=P11362-1; Sequence=Displayed; Name=2; Synonyms=Alpha A2; IsoId=P11362-8; Sequence=VSP 009842, VSP 009843; Name=3; Synon

Subcellular localization

Membrane;Single-pass type I membrane protein.

Gene name

fibroblast growth factor receptor 1

Related liver disease name

Hepatocellular carcinoma

Protein sequence

MWSWKCLLFWAVLVTATLCTARPSPTLPEQAQPWGAPVEV ESFLVHPGDLLQLRCRLRDDVQSINWLRDGVQLAESNRT RITGEEVEVQDSVPADSGLYACVTSSPSGSDTTYFSVNV SDALPSSEDDDDDDDSSSEEKETDNTKPNRMPVAPYWTS PEKMEKKLHAVPAAKTVKFKCPSSGTPNPTLRWLKNGKE FKPDHRIGGYKVRYATWSIIMDSVVPSDKGNYTCIVENE YGSINHTYQLDVVERSPHRPILQAGLPANKTVALGSNVE FMCKVYSDPQPHIQWLKHIEVNGSKIGPDNLPYVQILKT AGVNTTDKEMEVLHLRNVSFEDAGEYTCLAGNSIGLSHH SAWLTVLEALEERPAVMTSPLYLEIIIYCTGAFLISCMV GSVIVYKMKSGTKKSDFHSQMAVHKLAKSIPLRRQVTVS ADSSASMNSGVLLVRPSRLSSSGTPMLAGVSEYELPEDP RWELPRDRLVLGKPLGEGCFGQVVLAEAIGLDKDKPNRV TKVAVKMLKSDATEKDLSDLISEMEMMKMIGKHKNIINL LGACTQDGPLYVIVEYASKGNLREYLQARRPPGLEYCYN PSHNPEEQLSSKDLVSCAYQVARGMEYLASKKCIHRDLA ARNVLVTEDNVMKIADFGLARDIHHIDYYKKTTNGRLPV KWMAPEALFDRIYTHQSDVWSFGVLLWEIFTLGGSPYPG VPVEELFKLLKEGHRMDKPSNCTNELYMMMRDCWHAVPS QRPTFKQLVEDLDRIVALTSNQEYLDLSMPLDQYSPSFP DTRSSTCSSGEDSVFSHEPLPEEPCLPRHPAQLANGGLKRR

Database cross reference

RefSeq Protein accession:NP_001167534
RefSeq Protein gi:291327489

Liver relevance

HCC significant Proteins

Yes/No

Yes

Quality score

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;French Liver;

Ontology annotation

GO-C

GO:0005576;C:extracellular region;NAS:UniProtKB. GO:0005887;C:integral to plasma membrane;TAS:ProtInc. GO:0005624;C:membrane fraction;NAS:UniProtKB.

GO-F

GO:0005524;F:ATP binding;NAS:UniProtKB. GO:0005007;F:fibroblast growth factor receptor activity;IDA:UniProtKB. GO:0008201;F:heparin binding;NAS:UniProtKB. GO:0042803;F:protein homodimerization activity;IPI:UniProtKB.

GO-P

GO:0007411;P:axon guidance;TAS:Reactome. GO:0016049;P:cell growth;NAS:UniProtKB. GO:0008286;P:insulin receptor signaling pathway;TAS:Reactome. GO:0000165;P:M Error!!! Error!!!Go back to the login page