HuLPr23419

Uniprot ID

FGRL1_HUMAN

Uniprot Acc

Q8N441;B2RAU9;Q6PJN1;Q9BXN7;Q9H4D7;

Protein name

Fibroblast growth factor receptor-like 1

Comment

FUNCTION:Has a negative effect on cell proliferation (By similarity).||SUBUNIT:Interacts with FGF2 with a low affinity (By similarity).||SUBCELLULAR LOCATION:Membrane; Single-pass type I membrane protein. Note=Predominantly localized in the plasma membrane but also detected in the Golgi and in secretory vesicles.||TISSUE SPECIFICITY:Expressed preferentially in cartilaginous tissues and pancreas. Highly expressed in the liver, kidney, heart, brain and skeletal muscle. Weakly expressed in the lung, small intestine and spleen.||SIMILARITY:Contains 3 Ig-like C2-type (immunoglobulin-like) domains.

Subcellular localization

Membrane;Single-pass type I membrane protein.

Gene name

fibroblast growth factor receptor-like 1

Protein sequence

MTPSPLLLLLLPPLLLGAFPPAAAARGPPKMADKVVPRQV ARLGRTVRLQCPVEGDPPPLTMWTKDGRTIHSGWSRFRV LPQGLKVKQVEREDAGVYVCKATNGFGSLSVNYTLVVLD DISPGKESLGPDSSSGGQEDPASQQWARPRFTQPSKMRR RVIARPVGSSVRLKCVASGHPRPDITWMKDDQALTRPEA AEPRKKKWTLSLKNLRPEDSGKYTCRVSNRAGAINATYK VDVIQRTRSKPVLTGTHPVNTTVDFGGTTSFQCKVRSDV KPVIQWLKRVEYGAEGRHNSTIDVGGQKFVVLPTGDVWS RPDGSYLNKLLITRARQDDAGMYICLGANTMGYSFRSAF LTVLPDPKPPGPPVASSSSATSLPWPVVIGIPAGAVFIL GTLLLWLCQAQKKPCTPAPAPPLPGHRPPGTARDRSGDK DLPSLAALSAGPGVGLCEEHGSPAAPQHLLGPGPVAGPK LYPKLYTDIHTHTHTHSHTHSHVEGKVHQHIHYQC

Database cross reference

RefSeq Protein accession:NP_001004356
RefSeq Protein gi:51988912

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

GO:0016021;C:integral to membrane;IEA:UniProtKB-KW. GO:0005886;C:plasma membrane;IDA:UniProtKB.

GO-F

GO:0005007;F:fibroblast growth factor receptor activity;IDA:UniProtKB. GO:0008201;F:heparin binding;IDA:UniProtKB.

GO-P

GO:0001558;P:regulation of cell growth;NAS:UniProtKB.