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Protein basic information

LiverAtlas Protein ID

HuLPr23436

Uniprot ID

FIBA_HUMAN

Uniprot Acc

P02671;D3DP14;D3DP15;Q4QQH7;Q9BX62;Q9UCH2;

Protein name

Fibrinogen alpha chain

Comment

FUNCTION:Fibrinogen has a double function:yielding monomers that polymerize into fibrin and acting as a cofactor in platelet aggregation.||SUBUNIT:Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.||INTERACTION:Q92876:KLK6; NbExp=1; IntAct=EBI-348571, EBI-2432309; P48634:PRRC2A; NbExp=1; IntAct=EBI-348571, EBI-347545;||SUBCELLULAR LOCATION:Secreted.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; Synonyms=Alpha-E; IsoId=P02671-1; Sequence=Displayed; Name=2; Synonyms=Alpha; IsoId=P02671-2; Sequence=VSP 001531, VSP 001532; Note=Ref.3 (AAK31372) sequence is in conflict in positions: 640:PSLSP->LPCPPRLS;||TISSUE SPECIFICITY:Plasma.||DOMAIN:A long coiled coil structure formed by 3 polypeptide chains connects the central nodule to the C-terminal domains (distal nodules). The long C-terminal ends of the alpha cha

Subcellular localization

Secreted.

Gene name

fibrinogen alpha chain

Related liver disease name

Hepatocellular carcinoma

Protein sequence

MFSMRIVCLVLSVVGTAWTADSGEGDFLAEGGGVRGPRVV ERHQSACKDSDWPFCSDEDWNYKCPSGCRMKGLIDEVNQ DFTNRINKLKNSLFEYQKNNKDSHSLTTNIMEILRGDFS SANNRDNTYNRVSEDLRSRIEVLKRKVIEKVQHIQLLQK NVRAQLVDMKRLEVDIDIKIRSCRGSCSRALAREVDLKD YEDQQKQLEQVIAKDLLPSRDRQHLPLIKMKPVPDLVPG NFKSQLQKVPPEWKALTDMPQMRMELERPGGNEITRGGS TSYGTGSETESPRNPSSAGSWNSGSSGPGSTGNRNPGSS GTGGTATWKPGSSGPGSTGSWNSGSSGTGSTGNQNPGSP RPGSTGTWNPGSSERGSAGHWTSESSVSGSTGQWHSESG SFRPDSPGSGNARPNNPDWGTFEEVSGNVSPGTRREYHT EKLVTSKGDKELRTGKEKVTSGSTTTTRRSCSKTVTKTV IGPDGHKEVTKEVVTSEDGSDCPEAMDLGTLSGIGTLDG FRHRHPDEAAFFDTASTGKTFPGFFSPMLGEFVSETESR GSESGIFTNTKESSSHHPGIAEFPSRGKSSSYSKQFTSS TSYNRGDSTFESKSYKMADEAGSEADHEGTHSTKRGHAK SRPVRDCDDVLQTHPSGTQSGIFNIKLPGSSKIFSVYCD QETSLGGWLLIQQRMDGSLNFNRTWQDYKRGFGSLNDEG EGEFWLGNDYLHLLTQRGSVLRVELEDWAGNEAYAEYHF RVGSEAEGYALQVSSYEGTAGDALIEGSVEEGAEYTSHN NMQFSTFDRDADQWEENCAEVYGGGWWYNNCQAANLNGI YYPGGSYDPRNNSPYEIENGVVWVSFRGADYSLRAVRMKIRPLVTQ

Database cross reference

RefSeq Protein accession:NP_000499
RefSeq Protein gi:4503689

Liver relevance

HCC significant Proteins

Yes/No

Yes

Quality score

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;French Liver;Human Fetal Liver;

Ontology annotation

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GO-C

GO:0009897;C:external side of plasma membrane;IDA:BHF-UCL. GO:0005577;C:fibrinogen complex;TAS:ProtInc. GO:0031093;C:platelet alpha granule lumen;TAS:Reactome.

GO-F

GO:0043499;F:eukaryotic cell surface binding;IDA:BHF-UCL. GO:0030674;F:protein binding, bridging;IEA:InterPro. GO:0005102;F:receptor binding;IEA:InterPro.

GO-P

GO:0030168;P:platelet activation;TAS:Reactome. GO:0002576;P:platelet degranulation;TAS:Reactome. GO:0051258;P:protein polymerization;IEA:InterPro. GO:0051592;P:response to calcium ion;IDA:BHF-UCL. GO:0007165;P:signal transduction;IEA:InterPro.