HuLPr23450

Uniprot ID

FINC_HUMAN

Uniprot Acc

P02751;O95609;O95610;Q14312;Q14325;Q14326;Q17RV7;Q585T2;Q59EH1;Q60FE4;Q68DP8;Q68DP9;Q68DT4;Q6LDP6;Q6MZS0;Q6MZU5;Q6N025;Q6N0A6;Q86T27;Q8IVI8;Q96KP7;Q96KP8;Q96KP9;Q9H1B8;Q9HAP3;Q9UMK2;

Protein name

Fibronectin

Comment

FUNCTION:Fibronectins bind cell surfaces and various compounds including collagen, fibrin, heparin, DNA, and actin. Fibronectins are involved in cell adhesion, cell motility, opsonization, wound healing, and maintenance of cell shape.||FUNCTION:Anastellin binds fibronectin and induces fibril formation. This fibronectin polymer, named superfibronectin, exhibits enhanced adhesive properties. Both anastellin and superfibronectin inhibit tumor growth, angiogenesis and metastasis. Anastellin activates p38 MAPK and inhibits lysophospholipid signaling.||SUBUNIT:Mostly heterodimers or multimers of alternatively spliced variants, connected by 2 disulfide bonds near the carboxyl ends; to a lesser extent homodimers. Interacts with FBLN1, AMBP, TNR, LGALS3BP and COL13A1. Interacts with FBLN7 (By similarity). Interacts with COMP. Interacts with S.aureus fnbA. Interacts with TNR; the interaction inhibits cell adhesion and neurite outgrowth (By similarity). Interacts with FST3.||INTERACTION:P07996:TH

Subcellular localization

Secreted, extracellular space, extracellular matrix.

Gene name

fibronectin 1

Related liver disease name

Hepatocellular carcinoma

Protein sequence

MLRGPGPGLLLLAVQCLGTAVPSTGASKSKRQAQQMVQPQ SPVAVSQSKPGCYDNGKHYQINQQWERTYLGNALVCTCY GGSRGFNCESKPEAEETCFDKYTGNTYRVGDTYERPKDS MIWDCTCIGAGRGRISCTIANRCHEGGQSYKIGDTWRRP HETGGYMLECVCLGNGKGEWTCKPIAEKCFDHAAGTSYV VGETWEKPYQGWMMVDCTCLGEGSGRITCTSRNRCNDQD TRTSYRIGDTWSKKDNRGNLLQCICTGNGRGEWKCERHT SVQTTSSGSGPFTDVRAAVYQPQPHPQPPPYGHCVTDSG VVYSVGMQWLKTQGNKQMLCTCLGNGVSCQETAVTQTYG GNSNGEPCVLPFTYNGRTFYSCTTEGRQDGHLWCSTTSN YEQDQKYSFCTDHTVLVQTRGGNSNGALCHFPFLYNNHN YTDCTSEGRRDNMKWCGTTQNYDADQKFGFCPMAAHEEI CTTNEGVMYRIGDQWDKQHDMGHMMRCTCVGNGRGEWTC IAYSQLRDQCIVDDITYNVNDTFHKRHEEGHMLNCTCFG QGRGRWKCDPVDQCQDSETGTFYQIGDSWEKYVHGVRYQ CYCYGRGIGEWHCQPLQTYPSSSGPVEVFITETPSQPNS HPIQWNAPQPSHISKYILRWRPKNSVGRWKEATIPGHLN SYTIKGLKPGVVYEGQLISIQQYGHQEVTRFDFTTTSTS TPVTSNTVTGETTPFSPLVATSESVTEITASSFVVSWVS ASDTVSGFRVEYELSEEGDEPQYLDLPSTATSVNIPDLL PGRKYIVNVYQISEDGEQSLILSTSQTTAPDAPPDTTVD QVDDTSIVVRWSRPQAPITGYRIVYSPSVEGSSTELNLP ETANSVTLSDLQPGVQYNITIYAVEENQESTPVVIQQET TGTPRSDTVPSPRDLQFVEVTDVKVTIMWTPPESAVTGY RVDVIPVNLPGEHGQRLPISRNTFAEVTGLSPGVTYYFK VFAVSHGRESKPLTAQQTTKLDAP

Database cross reference

RefSeq Protein accession:NP_002017
RefSeq Protein gi:16933542

HCC significant Proteins

Yes/No

Yes

Quality score

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Fetal Liver;French Liver;Human Liver Organelles;

GO:0005793;C:ER-Golgi intermediate compartment;IDA:UniProtKB. GO:0005577;C:fibrinogen complex;IDA:BHF-UCL. GO:0031093;C:platelet alpha granule lumen;TAS:Reactome. GO:0005578;C:proteinaceous extracellular matrix;NAS:UniProtKB.

GO-F

GO:0005518;F:collagen binding;NAS:UniProtKB. GO:0005201;F:extracellular matrix structural constituent;NAS:UniProtKB. GO:0008201;F:heparin binding;NAS:UniProtKB.

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