Protein basic information
| LiverAtlas Protein ID |
HuLPr23519 |
|
Uniprot ID |
|
|
Uniprot Acc |
Q9P278;Q05DC3;Q96I31;Q9H994; |
|
Protein name |
Folliculin-interacting protein 2 |
|
Comment |
FUNCTION:May play a role in the signal transduction pathway of apoptosis induced by O6-methylguanine-mispaired lesions (By similarity). May be involved in energy and/or nutrient sensing through the AMPK and mTOR signaling pathways. May regulate phosphorylation of RPS6KB1.||SUBUNIT:Forms homomultimers and heteromultimers with FNIP1. Interacts (via C-terminus) with FLCN (via C-terminus). Phosphorylated FLCN is preferentially bound. Interacts with PRKAA1, PRKAB1 and PRKAG1 subunits of 5'-AMP-activated protein kinase.||SUBCELLULAR LOCATION:Cytoplasm. Note=Co-localizes with FLCN in the cytoplasm.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q9P278-1; Sequence=Displayed; Name=2; IsoId=Q9P278-2; Sequence=VSP 031656;||TISSUE SPECIFICITY:Widely expressed with highest levels in muscle, nasal mucosa, salivary gland, uvula, fat, liver, heart, placenty and pancreas. Moderately expressed in the lung, small intestine, kidney and brain. Lower levels detected in |
|
Subcellular localization |
Cytoplasm. |
|
Gene name |
|
|
Protein sequence
|
MAPTLLQKLFNKRGSSGSSAAASAQGRAPKEGPAFSWSCS EFDLNEIRLIVYQDCDRRGRQVLFDSKAVQKIEEVTAQK TEDVPIKISAKCCQGSSSVSSSSSSSISSHSSSGGSSHH AKEQLPKYQYTRPASDVNMLGEMMFGSVAMSYKGSTLKI HYIRSPPQLMISKVFSARMGSFCGSTNNLQDSFEYINQD PNLGKLNTNQNSLGPCRTGSNLAHSTPVDMPSRGQNEDR DSGIARSASLSSLLITPFPSPSSSTSSSSSYQRRWLRSQ TTSLENGIIPRRSTDETFSLAEETCSSNPAMVRRKKIAI SIIFSLCEKEEAQRNFQDFFFSHFPLFESHMNRLKSAIE KAMISCRKIAESSLRVQFYVSRLMEALGEFRGTIWNLYS VPRIAEPVWLTMMSGTLEKNQLCQRFLKEFTLLIEQINK NQFFAALLTAVLTYHLAWVPTVMPVDHPPIKAFSEKRTS QSVNMLAKTHPYNPLWAQLGDLYGAIGSPVRLTRTVVVG KQKDLVQRILYVLTYFLRCSELQENQLTWSGNHGEGDQV LNGSKIITALEKGEVEESEYVVITVRNEPALVPPILPPT AAERHNPWPTGFPECPEGTDSRDLGLKPDKEANRRPEQG SEACSAGCLGPASDASWKPQNAFCGDEKNKEAPQDGSSR LPSCEVLGAGMKMDQQAVCELLKVEMPTRLPDRSVAWPC PDRHLREKPSLEKVTFQIGSFASPESDFESRMKKMEERV KACGPSLEASEAADVAQDPQVSRSPFKPGFQENVCCPQN RLSEGDEGESDKGFAEDRGSRNDMAADIAGQLSHAADLG TASHGAGGTGGRRLEATRGLYVKAAEGPVLEPVAPRCVQ RGPGLVAGANIPCGDDNKKANFRTEGDIPRNESSDSALG DSDDEACASAMLDLGHGGDRTGGSLEVELPLPRSQSIST QNVRNFGRSLLAGYCPTYMPDLVLHGTGSDEKLKQCLVA DLVHTVHHPVLDEPIAEAVCIIAD |
|
Database cross reference |
RefSeq Protein accession:NP_065891
|
Liver relevance
|
HLPP validation |
Yes/No |
Yes |
|
Project name |
Human Liver Organelles;French Liver; |
Ontology annotation
| GO-C |
GO:0005737;C:cytoplasm;IDA:UniProtKB. |
|
GO-F |
GO:0005515;F:protein binding;IPI:UniProtKB. |
|
GO-P |
GO:0008630;P:DNA damage response, signal transduction resulting in induction of apoptosis;ISS:UniProtKB. GO:0006468;P:protein phosphorylation;IDA:UniProtKB. GO:0001932;P:regulation of protein phosphorylation;IDA:UniProtKB. |
Post-translational modification
| LiverAtlas Protein ID |
MOD type1 |
Position1 |
Residue1 |
Source name1 |
source ID1 |
Source method |
HLPP validation1 (Yes/no) |
Quality score |
|
HuLPr23519 |
PHOSPHORYLATION |
726 |
S |
PhosphoSitePlus |
LTP |
N |
 
|
|
|
HuLPr23519 |
PHOSPHORYLATION |
723 |
S |
PhosphoSitePlus |
LTP |
N |
|
|
|
HuLPr23519 |
ACETYLATION |
67 |
K |
PhosphoSitePlus |
HTP |
N |
|
