HuLPr23566

Uniprot ID

FOXO6_HUMAN

Uniprot Acc

A8MYZ6;

Protein name

Forkhead box protein O6

Comment

FUNCTION:Transcriptional activator (By similarity).||SUBCELLULAR LOCATION:Cytoplasm (By similarity). Nucleus (By similarity). Note=When phosphorylated, translocated from nucleus to cytoplasm. High nuclear localization after stimulation with growth factors (By similarity).||PTM:Phosphorylation of Ser-184 is be important in regulating the transacriptional activity (By similarity).||SIMILARITY:Contains 1 fork-head DNA-binding domain.

Subcellular localization

Cytoplasm(By similarity).Nucleus(By similarity).

Gene name

forkhead box O6

Protein sequence

MAAKLRAHQVDVDPDFAPQSRPRSCTWPLPQPDLAGDEDG ALGAGVAEGAEDCGPERRATAPAMAPAPPLGAEVGPLRK AKSSRRNAWGNLSYADLITKAIESAPDKRLTLSQIYDWM VRYVPYFKDKGDSNSSAGWKNSIRHNLSLHTRFIRVQNE GTGKSSWWMLNPEGGKTGKTPRRRAVSMDNGAKFLRIKG KASKKKQLQAPERSPDDSSPSAPAPGPVPAAAKWAASPA SHASDDYEAWADFRGGGRPLLGEAAELEDDEALEALAPS SPLMYPSPASALSPALGSRCPGELPRLAELGGPLGLHGG GGAGLPEGLLDGAQDAYGPRPAPRPGPVLGAPGELALAG AAAAYPGKGAAPYAPPAPSRSALAHPISLMTLPGEAGAA GLAPPGHAAAFGGPPGGLLLDALPGPYAAAAAGPLGAAP DRFPADLDLDMFSGSLECDVESIILNDFMDSDEMDFNFD SALPPPPPGLAGAPPPNQSWVPG

Database cross reference

RefSeq Protein accession:XP_002342143
RefSeq Protein gi:310118576

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

GO:0005829;C:cytosol;IBA:RefGenome. GO:0005667;C:transcription factor complex;IBA:RefGenome.

GO-F

GO:0008301;F:DNA bending activity;IBA:RefGenome. GO:0003690;F:double-stranded DNA binding;IBA:RefGenome. GO:0010843;F:promoter binding;IBA:RefGenome. GO:0019901;F:protein kinase binding;IBA:RefGenome. GO:0043565;F:sequence-specific DNA binding;IEA:Inte

GO-P

GO:0009790;P:embryo development;IBA:RefGenome. GO:0008286;P:insulin receptor signaling pathway;IBA:RefGenome. GO:0016525;P:negative regulation of angiogenesis;IBA:RefGenome. GO:0008285;P:negative regulation of cell proliferation;IBA:RefGenome. GO:00511