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Protein basic information

LiverAtlas Protein ID

HuLPr23709

Uniprot ID

G3ST1_HUMAN

Uniprot Acc

Q99999;Q96C63;

Protein name

Galactosylceramide sulfotransferase

Comment

FUNCTION:Catalyzes the sulfation of membrane glycolipids. Seems to prefer beta-glycosides at the non-reducing termini of sugar chains attached to a lipid moiety. Catalyzes the synthesis of galactosylceramide sulfate (sulfatide), a major lipid component of the myelin sheath and of monogalactosylalkylacylglycerol sulfate (seminolipid), present in spermatocytes (By similarity). Also acts on lactosylceramide, galactosyl 1-alkyl-2-sn-glycerol and galactosyl diacylglycerol (in vitro).||CATALYTIC ACTIVITY:3'-phosphoadenylyl sulfate + a galactosylceramide = adenosine 3',5'-bisphosphate + a galactosylceramidesulfate.||CATALYTIC ACTIVITY:3'-phosphoadenylyl sulfate + monogalactosylalkylacylglycerol = adenosine 3',5'-bisphosphate + monogalactosylalkylacylglycerol sulfate.||PATHWAY:Lipid metabolism; sphingolipid metabolism.||SUBCELLULAR LOCATION:Golgi apparatus membrane; Single-pass type II membrane protein (By similarity).||TISSUE SPECIFICITY:Expressed in kidney proximal tubule, gastric mucosa and

Subcellular localization

Golgi apparatus membrane;Single-pass type II membrane protein(By similarity).

Gene name

galactose-3-O-sulfotransferase 1

Protein sequence

MLPPQKKPWESMAKGLVLGALFTSFLLLVYSYAVPPLHAG LASTTPEAAASCSPPALEPEAVIRANGSAGECQPRRNIV FLKTHKTASSTLLNILFRFGQKHRLKFAFPNGRNDFDYP TFFARSLVQDYRPGACFNIICNHMRFHYDEVRGLVPTNA IFITVLRDPARLFESSFHYFGPVVPLTWKLSAGDKLTEF LQDPDRYYDPNGFNAHYLRNLLFFDLGYDNSLDPSSPQV QEHILEVERRFHLVLLQEYFDESLVLLKDLLCWELEDVL YFKLNARRDSPVPRLSGELYGRATAWNMLDSHLYRHFNA SFWRKVEAFGRERMAREVAALRHANERMRTICIDGGHAV DAAAIQDEAMQPWQPLGTKSILGYNLKKSIGQRHAQLCR RMLTPEIQYLMDLGANLWVTKLWKFIRDFLRW

Database cross reference

RefSeq Protein accession:NP_004852
RefSeq Protein gi:4758088

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;

Ontology annotation

GO-C

GO:0000139;C:Golgi membrane;IEA:UniProtKB-SubCell. GO:0005887;C:integral to plasma membrane;TAS:ProtInc. GO:0005624;C:membrane fraction;TAS:ProtInc.

GO-F

GO:0001733;F:galactosylceramide sulfotransferase activity;IEA:EC.

GO-P

GO:0006487;P:protein N-linked glycosylation;TAS:ProtInc.

Pathway

Pathway name

Sphingolipid_Metabolism