HuLPr23771

Uniprot ID

GALT3_HUMAN

Uniprot Acc

Q14435;Q53TG9;Q7Z476;

Protein name

Polypeptide N-acetylgalactosaminyltransferase 3

Comment

FUNCTION:Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D- galactosamine residue to a serine or threonine residue on the protein receptor. Has activity toward HIV envelope glycoprotein gp120, EA2, Muc2 and Muc5. Probably glycosylates fibronectin in vivo. Glycosylates FGF23. Plays a central role in phosphate homeostasis.||CATALYTIC ACTIVITY:UDP-N-acetyl-D-galactosamine + polypeptide = UDP + N-acetyl-D-galactosaminyl-polypeptide.||COFACTOR:Manganese (By similarity).||COFACTOR:Calcium (By similarity).||PATHWAY:Protein modification; protein glycosylation.||SUBCELLULAR LOCATION:Golgi apparatus, Golgi stack membrane; Single-pass type II membrane protein. Note=Resides preferentially in the trans and medial parts of the Golgi stack.||ALTERNATIVE PRODUCTS:Event=Alternative splicing; Named isoforms=2; Name=1; IsoId=Q14435-1; Sequence=Displayed; Name=2; IsoId=Q14435-2; Sequence=VSP 011202, VSP 011203; Note=No experimental confirmation av

Subcellular localization

Golgi apparatus, Golgi stack membrane;Single-pass type II membrane protein.

Gene name

UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 3 (GalNAc-T3)

Protein sequence

MAHLKRLVKLHIKRHYHKKFWKLGAVIFFFIIVLVLMQRE VSVQYSKEESRMERNMKNKNKMLDLMLEAVNNIKDAMPK MQIGAPVRQNIDAGERPCLQGYYTAAELKPVLDRPPQDS NAPGASGKAFKTTNLSVEEQKEKERGEAKHCFNAFASDR ISLHRDLGPDTRPPECIEQKFKRCPPLPTTSVIIVFHNE AWSTLLRTVHSVLYSSPAILLKEIILVDDASVDEYLHDK LDEYVKQFSIVKIVRQRERKGLITARLLGATVATAETLT FLDAHCECFYGWLEPLLARIAENYTAVVSPDIASIDLNT FEFNKPSPYGSNHNRGNFDWSLSFGWESLPDHEKQRRKD ETYPIKTPTFAGGLFSISKEYFEYIGSYDEEMEIWGGEN IEMSFRVWQCGGQLEIMPCSVVGHVFRSKSPHSFPKGTQ VIARNQVRLAEVWMDEYKEIFYRRNTDAAKIVKQKAFGD LSKRFEIKHRLQCKNFTWYLNNIYPEVYVPDLNPVISGY IKSVGQPLCLDVGENNQGGKPLIMYTCHGLGGNQYFEYS AQHEIRHNIQKELCLHAAQGLVQLKACTYKGHKTVVTGE QIWEIQKDQLLYNPFLKMCLSANGEHPSLVSCNPSDPLQKWILSQND

Database cross reference

RefSeq Protein accession:NP_004473
RefSeq Protein gi:153266878

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

GO:0032580;C:Golgi cisterna membrane;IEA:UniProtKB-SubCell. GO:0016021;C:integral to membrane;TAS:ProtInc. GO:0005624;C:membrane fraction;TAS:ProtInc. GO:0005634;C:nucleus;IDA:HPA. GO:0048471;C:perinuclear region of cytoplasm;IDA:BHF-UCL.

GO-F

GO:0005509;F:calcium ion binding;IDA:BHF-UCL. GO:0030145;F:manganese ion binding;IDA:BHF-UCL. GO:0004653;F:polypeptide N-acetylgalactosaminyltransferase activity;IDA:BHF-UCL. GO:0005529;F:sugar binding;IEA:UniProtKB-KW.

GO-P

GO:0018242;P:protein O-linked glycosylation via serine;IDA:BHF-UCL. GO:0018243;P:protein O-linked glycosylation via threonine;IDA:UniProtKB.

IL2