HuLPr23825

Uniprot ID

GBLP_HUMAN

Uniprot Acc

P63244;B3KTJ0;D3DWS0;P25388;P99049;Q53HU2;Q5J8M6;Q5VLR4;Q6FH47;

Protein name

Guanine nucleotide-binding protein subunit beta-2-like 1

Comment

FUNCTION:Involved in the recruitment, assembly and/or regulation of a variety of signaling molecules. Interacts with a wide variety of proteins and plays a role in many cellular processes. Component of the 40S ribosomal subunit involved in translational repression. Binds to and stabilizes activated protein kinase C (PKC), increasing PKC-mediated phosphorylation. May recruit activated PKC to the ribosome, leading to phosphorylation of EIF6. Inhibits the activity of SRC kinases including SRC, LCK and YES1. Inhibits cell growth by prolonging the G0/G1 phase of the cell cycle. Enhances phosphorylation of BMAL1 by PRKCA and inhibits transcriptional activity of the BMAL1-CLOCK heterodimer. Facilitates ligand- independent nuclear translocation of AR following PKC activation, represses AR transactivation activity and is required for phosphorylation of AR by SRC. Modulates IGF1R-dependent integrin signaling and promotes cell spreading and contact with the extracellular matrix. Involved in PKC-d

Subcellular localization

Cell membrane;Peripheral membrane protein.Cytoplasm.Cytoplasm, perinuclear region.Cytoplasm, cytoskeleton.Nucleus.Perikaryon(By similarity).Cell projection, dendrite(By similarity).Cell projection, phagocytic cup.

Gene name

guanine nucleotide binding protein (G protein), beta polypeptide 2-like 1

Related liver disease name

Hepatocellular carcinoma

Protein sequence

MTEQMTLRGTLKGHNGWVTQIATTPQFPDMILSASRDKTI IMWKLTRDETNYGIPQRALRGHSHFVSDVVISSDGQFAL SGSWDGTLRLWDLTTGTTTRRFVGHTKDVLSVAFSSDNR QIVSGSRDKTIKLWNTLGVCKYTVQDESHSEWVSCVRFS PNSSNPIIVSCGWDKLVKVWNLANCKLKTNHIGHTGYLN TVTVSPDGSLCASGGKDGQAMLWDLNEGKHLYTLDGGDI INALCFSPNRYWLCAATGPSIKIWDLEGKIIVDELKQEV ISTSSKAEPPQCTSLAWSADGQTLFAGYTDNLVRVWQVTIGTR

Database cross reference

RefSeq Protein accession:NP_006089
RefSeq Protein gi:5174447

HCC significant Proteins

Yes/No

Yes

Quality score

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

GO:0030425;C:dendrite;ISS:UniProtKB. GO:0030496;C:midbody;IDA:UniProtKB. GO:0043025;C:neuronal cell body;ISS:UniProtKB. GO:0005634;C:nucleus;IDA:UniProtKB. GO:0048471;C:perinuclear region of cytoplasm;IDA:UniProtKB. GO:0001891;C:phagocytic cup;IDA:Uni

GO-F

GO:0008200;F:ion channel inhibitor activity;ISS:UniProtKB. GO:0005080;F:protein kinase C binding;IDA:UniProtKB. GO:0019903;F:protein phosphatase binding;IPI:UniProtKB. GO:0030292;F:protein tyrosine kinase inhibitor activity;IDA:UniProtKB. GO:0030971;F:

GO-P

GO:0030308;P:negative regulation of cell growth;IDA:UniProtKB. GO:0050765;P:negative regulation of phagocytosis;IMP:UniProtKB. GO:0017148;P:negative regulation of translation;ISS:UniProtKB. GO:0030178;P:negative regulation of Wnt receptor signaling path