HuLPr23840

Uniprot ID

GBRB1_HUMAN

Uniprot Acc

P18505;B2R6U7;Q16166;Q8TBK3;

Protein name

Gamma-aminobutyric acid receptor subunit beta-1

Comment

FUNCTION:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel.||SUBUNIT:Binds UBQLN1 (By similarity). Generally pentameric. There are five types of GABA(A) receptor chains:alpha, beta, gamma, delta, and rho. Interacts with KCTD8, KCTD12 and KCTD16; this interaction determines the pharmacology and kinetics of the receptor response, the KCTD proteins markedly accelerating the GABA-B response, although to different extents (By similarity).||SUBCELLULAR LOCATION:Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.||SIMILARITY:Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRB1 sub-subfamily.||WEB RESOURCE:Name=Protein Spotlight; Note=Forbidden fruit - Issue 56 of March 2005; URL="http://www.expasy.org/spotlight/back is

Subcellular localization

Cell junction, synapse, postsynaptic cell membrane;Multi-pass membrane protein.Cell membrane;Multi-pass membrane protein.

Gene name

gamma-aminobutyric acid (GABA) A receptor, beta 1

Protein sequence

MWTVQNRESLGLLSFPVMITMVCCAHSTNEPSNMSYVKET VDRLLKGYDIRLRPDFGGPPVDVGMRIDVASIDMVSEVN MDYTLTMYFQQSWKDKRLSYSGIPLNLTLDNRVADQLWV PDTYFLNDKKSFVHGVTVKNRMIRLHPDGTVLYGLRITT TAACMMDLRRYPLDEQNCTLEIESYGYTTDDIEFYWNGG EGAVTGVNKIELPQFSIVDYKMVSKKVEFTTGAYPRLSL SFRLKRNIGYFILQTYMPSTLITILSWVSFWINYDASAA RVALGITTVLTMTTISTHLRETLPKIPYVKAIDIYLMGC FVFVFLALLEYAFVNYIFFGKGPQKKGASKQDQSANEKN KLEMNKVQVDAHGNILLSTLEIRNETSGSEVLTSVSDPK ATMYSYDSASIQYRKPLSSREAYGRALDRHGVPSKGRIR RRASQLKVKIPDLTDVNSIDKWSRMFFPITFSLFNVVYWLYYVH

Database cross reference

RefSeq Protein accession:NP_000803
RefSeq Protein gi:194097327

HLPP validation

Yes/No

Yes

Project name

Human Liver Organelles;

GO:0030054;C:cell junction;IEA:UniProtKB-KW. GO:0034707;C:chloride channel complex;IEA:UniProtKB-KW. GO:0005887;C:integral to plasma membrane;TAS:ProtInc. GO:0045211;C:postsynaptic membrane;IEA:UniProtKB-SubCell.

GO-F

GO:0005254;F:chloride channel activity;IEA:UniProtKB-KW. GO:0005230;F:extracellular ligand-gated ion channel activity;IEA:InterPro. GO:0004890;F:GABA-A receptor activity;TAS:ProtInc.

GO-P

GO:0007268;P:synaptic transmission;TAS:Reactome.

MOD type1

Position1

Residue1

Source name1

source ID1

Source method

HLPP validation1 (Yes/no)

Quality score

HuLPr23840

PHOSPHORYLATION

434

S

Phospho-ELM

1351

LTP

N

HuLPr23840

UBIQUITINATION

46

K

PhosphoSitePlus

6797126

LTP

HTP

N