HuLPr23850

Uniprot ID

GBRP_HUMAN

Uniprot Acc

O00591;A8KA36;D3DQL2;Q32MJ1;

Protein name

Gamma-aminobutyric acid receptor subunit pi

Comment

FUNCTION:GABA, the major inhibitory neurotransmitter in the vertebrate brain, mediates neuronal inhibition by binding to the GABA/benzodiazepine receptor and opening an integral chloride channel. In the uterus, the function of the receptor appears to be related to tissue contractility. The binding of this pI subunit with other GABA(A) receptor subunits alters the sensitivity of recombinant receptors to modulatory agents such as pregnanolone.||SUBUNIT:Generally pentameric. There are five types of GABA(A) receptor chains:alpha, beta, gamma, delta, and epsilon. A sixth class of subunit:Rho form homomeric GABA receptors that do not appear to coexist with GABA(A) receptor subunits but with GABA(C) receptor subunits. Subunit Pi can also bind this complex.||SUBCELLULAR LOCATION:Cell junction, synapse, postsynaptic cell membrane; Multi-pass membrane protein. Cell membrane; Multi-pass membrane protein.||TISSUE SPECIFICITY:Most abundant in the uterus, also expressed in lung, thymus and prostate.

Subcellular localization

Cell junction, synapse, postsynaptic cell membrane;Multi-pass membrane protein.Cell membrane;Multi-pass membrane protein.

Gene name

gamma-aminobutyric acid (GABA) A receptor, pi

Protein sequence

MNYSLHLAFVCLSLFTERMCIQGSQFNVEVGRSDKLSLPG FENLTAGYNKFLRPNFGGEPVQIALTLDIASISSISESN MDYTATIYLRQRWMDQRLVFEGNKSFTLDARLVEFLWVP DTYIVESKKSFLHEVTVGNRLIRLFSNGTVLYALRITTT VACNMDLSKYPMDTQTCKLQLESWGYDGNDVEFTWLRGN DSVRGLEHLRLAQYTIERYFTLVTRSQQETGNYTRLVLQ FELRRNVLYFILETYVPSTFLVVLSWVSFWISLDSVPAR TCIGVTTVLSMTTLMIGSRTSLPNTNCFIKAIDVYLGIC FSFVFGALLEYAVAHYSSLQQMAAKDRGTTKEVEEVSIT NIINSSISSFKRKISFASIEISSDNVDYSDLTMKTSDKF KFVFREKMGRIVDYFTIQNPSNVDHYSKLLFPLIFMLAN VFYWAYYMYF

Database cross reference

RefSeq Protein accession:NP_055026
RefSeq Protein gi:7657106

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;

GO:0030054;C:cell junction;IEA:UniProtKB-KW. GO:0034707;C:chloride channel complex;IEA:UniProtKB-KW. GO:0045211;C:postsynaptic membrane;IEA:UniProtKB-SubCell.

GO-F

GO:0005254;F:chloride channel activity;IEA:UniProtKB-KW. GO:0005230;F:extracellular ligand-gated ion channel activity;IEA:InterPro. GO:0004890;F:GABA-A receptor activity;TAS:ProtInc.