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Protein basic information

LiverAtlas Protein ID

HuLPr23891

Uniprot ID

GDE1_HUMAN

Uniprot Acc

Q9NZC3;O43334;Q6PKF7;Q7KYR4;

Protein name

Glycerophosphodiester phosphodiesterase 1

Comment

FUNCTION:Has glycerophosphoinositol phosphodiesterase activity. Has little or no activity towards glycerophosphocholine. GDE1 activity can be modulated by G-protein signaling pathways (By similarity).||CATALYTIC ACTIVITY:1-(sn-glycero-3-phospho)-1D-myo-inositol + H(2)O = myo-inositol + sn-glycerol 3-phosphate.||COFACTOR:Magnesium (By similarity).||SUBUNIT:Interacts with RGS16 (By similarity). Interacts with PRAF2.||SUBCELLULAR LOCATION:Cytoplasm (By similarity). Membrane; Multi- pass membrane protein (By similarity). Note=Perinuclear vesicles and cell membrane (By similarity).||TISSUE SPECIFICITY:Widely expressed.||PTM:N-glycosylated (By similarity).||SIMILARITY:Belongs to the glycerophosphoryl diester phosphodiesterase family.||SIMILARITY:Contains 1 GDPD domain.||SEQUENCE CAUTION:Sequence=AAC05440.1; Type=Erroneous gene model prediction; Sequence=AAC05803.1; Type=Erroneous gene model prediction;

Subcellular localization

Cytoplasm(By similarity).Membrane;Multi- pass membrane protein(By similarity).

Gene name

glycerophosphodiester phosphodiesterase 1

Protein sequence

MWLWEDQGGLLGPFSFLLLVLLLVTRSPVNACLLTGSLFV LLRVFSFEPVPSCRALQVLKPRDRISAIAHRGGSHDAPE NTLAAIRQAAKNGATGVELDIEFTSDGIPVLMHDNTVDR TTDGTGRLCDLTFEQIRKLNPAANHRLRNDFPDEKIPTL REAVAECLNHNLTIFFDVKGHAHKATEALKKMYMEFPQL YNNSVVCSFLPEVIYKMRQTDRDVITALTHRPWSLSHTG DGKPRYDTFWKHFIFVMMDILLDWSMHNILWYLCGISAF LMQKDFVSPAYLKKWSAKGIQVVGWTVNTFDEKSYYESH LGSSYITDSMVEDCEPHF

Database cross reference

RefSeq Protein accession:NP_057725
RefSeq Protein gi:7706617

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;French Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005737;C:cytoplasm;IEA:UniProtKB-SubCell. GO:0016021;C:integral to membrane;TAS:UniProtKB.

GO-F

GO:0008889;F:glycerophosphodiester phosphodiesterase activity;TAS:UniProtKB. GO:0047395;F:glycerophosphoinositol glycerophosphodiesterase activity;IEA:EC. GO:0046872;F:metal ion binding;IEA:UniProtKB-KW.

GO-P

GO:0006071;P:glycerol metabolic process;IEA:InterPro. GO:0006629;P:lipid metabolic process;TAS:UniProtKB.

Pathway

Pathway name

Phospholipid_Biosynthesis

Pathway name

FSH