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Gene, Transcriptome, Protein, Pathway or Disease. 

Protein basic information

LiverAtlas Protein ID

HuLPr23900

Uniprot ID

GDF7_HUMAN

Uniprot Acc

Q7Z4P5;

Protein name

Growth/differentiation factor 7

Comment

FUNCTION:May play an active role in the motor area of the primate neocortex (By similarity).||SUBUNIT:Homodimer; disulfide-linked (By similarity).||SUBCELLULAR LOCATION:Secreted (By similarity).||SIMILARITY:Belongs to the TGF-beta family.

Subcellular localization

Secreted(By similarity).

Gene name

growth differentiation factor 7

Protein sequence

MDLSAAAALCLWLLSACRPRDGLEAAAVLRAAGAGPVRSP GGGGGGGGGGRTLAQAAGAAAVPAAAVPRARAARRAAGS GFRNGSVVPHHFMMSLYRSLAGRAPAGAAAVSASGHGRA DTITGFTDQATQDESAAETGQSFLFDVSSLNDADEVVGA ELRVLRRGSPESGPGSWTSPPLLLLSTCPGAARAPRLLY SRAAEPLVGQRWEAFDVADAMRRHRREPRPPRAFCLLLR AVAGPVPSPLALRRLGFGWPGGGGSAAEERAVLVVSSRT QRKESLFREIRAQARALGAALASEPLPDPGTGTASPRAV IGGRRRRRTALAGTRTAQGSGGGAGRGHGRRGRSRCSRK PLHVDFKELGWDDWIIAPLDYEAYHCEGLCDFPLRSHLE PTNHAIIQTLLNSMAPDAAPASCCVPARLSPISILYIDA ANNVVYKQYEDMVVEACGCR

Database cross reference

RefSeq Protein accession:NP_878248
RefSeq Protein gi:61835232

Liver relevance

HLPP validation

Yes/No

Yes

Project name

Chinese Liver;Human Liver Organelles;

Ontology annotation

GO-C

GO:0005615;C:extracellular space;IEA:UniProtKB-KW.

GO-F

GO:0005125;F:cytokine activity;IEA:UniProtKB-KW. GO:0008083;F:growth factor activity;IEA:UniProtKB-KW.

GO-P

GO:0032924;P:activin receptor signaling pathway;IDA:BHF-UCL. GO:0030509;P:BMP signaling pathway;IDA:BHF-UCL. GO:0040007;P:growth;IEA:InterPro. GO:0060389;P:pathway-restricted SMAD protein phosphorylation;IDA:BHF-UCL. GO:0010862;P:positive regulation of